Protein detail
S38A5
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)
Protein symbol S38A5 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 11 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
49..71; Helical; 88..108; Helical; 126..146; Helical; 167..187; Helical; 193..213; Helical; 258..278; Helical; 296..316; Helical; 335..355; Helical; 377..397; Helical; 400..420; Helical; 440..460; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
JM24SN2
Gene Description
Solute carrier family 38 member 5
Chromosome
X
Position
48458537-48470260
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificFoveolar cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005290 L-histidine transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015182 L-asparagine transmembrane transporter activity
- GO:0015186 L-glutamine transmembrane transporter activity
- GO:0015187 glycine transmembrane transporter activity
- GO:0015194 L-serine transmembrane transporter activity
- GO:0022858 alanine transmembrane transporter activity
- GO:0140830 L-glutamine, sodium:proton antiporter activity
- GO:0140893 neutral amino acid, sodium:proton antiporter activity
Reactome
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 2 of 2Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains
Sequences
Length
472
Mass
51,457
Sequence
MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUX1-1; Sequence=Displayed; Name=2; IsoId=Q8WUX1-2; Sequence=VSP_029702
Alternative Sequence
1..51; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Clinical Relevance
Antibody