Protein detail

CTL1

Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)

Entry name CTL1	UniProt ID Q8WWI5	EVMP confidence score 0.63
Supporting publications (n) 31	Transmembrane count 9	Protein classification CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)

Protein Class (6)

CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
CD markers
Potential drug targets

Transmembrane

31..51; Helical; 213..233; Helical; 239..259; Helical; 289..309; Helical; 316..336; Helical; 339..359; Helical; 381..401; Helical; 538..558; Helical; 567..587; Helical

Transmembrane Count

Ensembl

ENSG00000070214

Entrez Gene Symbol

SLC44A1

Gene Synonym (4)

CD92CDW92CHTL1CTL1

Gene Description

Solute carrier family 44 member 1

Chromosome

Position

105244622-105439171

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization1

Cell SpecificPodocytes

Function & Pathway7

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
CD markers
Potential drug targets

Cellular Component (7)

Molecular Function (3)

Biological Process (3)

KEGG

hsa05231 Choline metabolism in cancer

Reactome (10)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
solute_carrier	transporter	Almen2009	No	Yes	No	Yes	No
slc44	transporter	Surfaceome	No	Yes	No	Yes	No
slc	transporter	Surfaceome	No	Yes	No	Yes	No

Page 1 of 3Next

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC44A1	Q8WWI5	2	PDB	PDB:7wwb

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Flow cytometry	2	37862381 38136601

Sequence, Structure & Domains10

Sequences

Length

657

Mass

73,302

Sequence

MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8WWI5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWI5-2; Sequence=VSP_015424, VSP_015425; Name=3; Synonyms=C; IsoId=Q8WWI5-3; Sequence=VSP_015426, VSP_015427

Alternative Sequence

651..654; ASGA -> LKKR (in isoform 2); 651..652; AS -> IK (in isoform 3); 653..657; Missing (in isoform 3); 655..657; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

635..648; Basic and acidic residues

Region

635..657; Disordered

Protein Families

CTL (choline transporter-like) family

Sequence Similarities

Belongs to the CTL (choline transporter-like) family.

Clinical Relevance2

Disease Involvement

Neurodegeneration

Antibody (2)

HPA064714 HPA074007

Supporting Publications31

PMID	Title	Abstract
23376485	Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.	No abstract available
2353145	[The Cronkhite-Canada syndrome].	No abstract available
27312428	A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.	No abstract available
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
31018934	Proteomic Analysis of Urinary Microvesicles and Exosomes in Medullary Sponge Kidney Disease and Autosomal Dominant Polycystic Kidney Disease.	No abstract available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
31588238	Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
32927759	Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease.	No abstract available
33580265	Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism.	No abstract available

Page 1 of 4Next