Protein detail
CTL1
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)
Entry name CTL1 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 31 | Transmembrane count 9 | Protein classification CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)
Protein Class (6)
CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- CD markers
- Potential drug targets
Transmembrane
31..51; Helical; 213..233; Helical; 239..259; Helical; 289..309; Helical; 316..336; Helical; 339..359; Helical; 381..401; Helical; 538..558; Helical; 567..587; Helical
Transmembrane Count
9
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CD92CDW92CHTL1CTL1
Gene Description
Solute carrier family 44 member 1
Chromosome
9
Position
105244622-105439171
Supporting publications (n)
31
EVMP confidence score
0.75
Fluorescence & Localization
Cell SpecificPodocytes
Function & Pathway
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- CD markers
- Potential drug targets
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Reactome (10)
- R-hsa-6798163 choline catabolism
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-556833 metabolism of lipids
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9958517 slc mediated bile acid transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-1483191 synthesis of pc
- R-hsa-382551 transport of small molecules
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
657
Mass
73,302
Sequence
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8WWI5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWI5-2; Sequence=VSP_015424, VSP_015425; Name=3; Synonyms=C; IsoId=Q8WWI5-3; Sequence=VSP_015426, VSP_015427
Alternative Sequence
651..654; ASGA -> LKKR (in isoform 2); 651..652; AS -> IK (in isoform 3); 653..657; Missing (in isoform 3); 655..657; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
635..648; Basic and acidic residues
Region
635..657; Disordered
Protein Families
CTL (choline transporter-like) family
Sequence Similarities
Belongs to the CTL (choline transporter-like) family.
Supporting Publications31
| PMID | Title | Related sentences |
|---|---|---|
| 23376485 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. | No related sentences available |
| 2353145 | [The Cronkhite-Canada syndrome]. | No related sentences available |
| 27312428 | A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer. | No related sentences available |
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No related sentences available |
| 31018934 | Proteomic Analysis of Urinary Microvesicles and Exosomes in Medullary Sponge Kidney Disease and Autosomal Dominant Polycystic Kidney Disease. | No related sentences available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No related sentences available |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 32927759 | Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease. | No related sentences available |
| 33580265 | Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism. | No related sentences available |
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