Protein detail

CTL1

Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)

Entry name CTL1	UniProt ID Q8WWI5	EVMP confidence score 0.63
Supporting publications (n) 31	Transmembrane count 9	Protein classification CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)

Protein Class (6)

CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
CD markers
Potential drug targets

Transmembrane

31..51; Helical; 213..233; Helical; 239..259; Helical; 289..309; Helical; 316..336; Helical; 339..359; Helical; 381..401; Helical; 538..558; Helical; 567..587; Helical

Transmembrane Count

Ensembl

ENSG00000070214

Entrez Gene Symbol

SLC44A1

Gene Synonym (4)

CD92CDW92CHTL1CTL1

Gene Description

Solute carrier family 44 member 1

Chromosome

Position

105244622-105439171

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization1

Cell SpecificPodocytes

Function & Pathway7

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
CD markers
Potential drug targets

Cellular Component (7)

Molecular Function (3)

Biological Process (3)

KEGG

hsa05231 Choline metabolism in cancer

Reactome (10)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC44A1	Q8WWI5	2	PDB	PDB:7wwb

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Flow cytometry	2	37862381 38136601

Sequence, Structure & Domains10

Sequences

Length

657

Mass

73,302

Sequence

MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8WWI5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWI5-2; Sequence=VSP_015424, VSP_015425; Name=3; Synonyms=C; IsoId=Q8WWI5-3; Sequence=VSP_015426, VSP_015427

Alternative Sequence

651..654; ASGA -> LKKR (in isoform 2); 651..652; AS -> IK (in isoform 3); 653..657; Missing (in isoform 3); 655..657; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

635..648; Basic and acidic residues

Region

635..657; Disordered

Protein Families

CTL (choline transporter-like) family

Sequence Similarities

Belongs to the CTL (choline transporter-like) family.

Clinical Relevance2

Disease Involvement

Neurodegeneration

Antibody (2)

HPA064714 HPA074007

Supporting Publications31

PMID	Title	Abstract
33729255	A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles.	No abstract available
34071777	Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways.	No abstract available
34867951	Circulating Exosome Involves in the Pathogenesis of Autoimmune Thyroid Diseases Through Immunomodulatory Proteins.	No abstract available
34889606	Surface Nanosieving Polyether Sulfone Particles with Graphene Oxide Encapsulation for the Negative Isolation toward Extracellular Vesicles.	No abstract available
36635400	Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
37702715	One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles.	No abstract available
38164498	Enrichment of sweat-derived extracellular vesicles of human and bacterial origin for biomarker identification.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
38871730	Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes.	No abstract available

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