Protein detail

ABCA5

Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5)

Entry name ABCA5	UniProt ID Q8WWZ7	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 15	Protein classification Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5)

Protein Class (4)

Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Primary Active Transporters
Predicted intracellular proteins

Transmembrane

32..52; Helical; 220..240; Helical; 264..284; Helical; 297..317; Helical; 328..348; Helical; 355..375; Helical; 396..416; Helical; 866..886; Helical; 967..987; Helical; 1021..1041; Helical; 1071..1091; Helical; 1102..1122; Helical; 1139..1159; Helical; 1169..1189; Helical; 1207..1227; Helical

Transmembrane Count

Ensembl

ENSG00000154265

Entrez Gene Symbol

ABCA5

Gene Synonym

EST90625

Gene Description

ATP binding cassette subfamily A member 5

Chromosome

Position

69244311-69327244

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue Specificadrenal glandCell SpecificEnterocytes

Function & Pathway8

Protein Function (3)

Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Primary Active Transporters
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (3)

Canonical Pathways

M82 Pid ret pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence19

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
abca	transporter	Surfaceome	No	Yes	No	No	No
active	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	2	38225453 38731868

Sequence, Structure & Domains10

Sequences

Length

1,642

Mass

186,508

Sequence

MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WWZ7-1; Sequence=Displayed; Name=2; Synonyms=V20+16; IsoId=Q8WWZ7-2; Sequence=VSP_020691, VSP_020692; Name=3; IsoId=Q8WWZ7-3; Sequence=VSP_020690

Alternative Sequence

1..777; Missing (in isoform 3); 922..925; DSDI -> GESV (in isoform 2); 926..1642; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1259..1268; Acidic residues

Domain (FT)

478..713; ABC transporter 1; 1290..1533; ABC transporter 2

Region

1249..1268; Disordered

Protein Families (2)

ABC transporter superfamily
ABCA family

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCA family.

Clinical Relevance2

Drugs

QUERCETIN-3'-O-PHOSPHATE

Antibody (2)

HPA022032 HPA062904

Supporting Publications1

PMID	Title	Abstract
38083799	Identification of ABCC3 and its isoforms as potential biomarker in hepatocellular carcinoma.	Therefore, we analyzed ABCC3 expression in public databases and investigated the presence of ABCC3 and its isoforms in plasma, urine and its release in extracellular vesicles (EVs) cargo from patients bearing cirrhosis and HCC.