Protein detail

ABCA5

Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5)

Entry name
ABCA5
UniProt ID
Q8WWZ7
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
15
Protein classification
Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5)
Protein Class (4)
Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Transporters:Primary Active Transporters
  • Predicted intracellular proteins
Transmembrane
32..52; Helical; 220..240; Helical; 264..284; Helical; 297..317; Helical; 328..348; Helical; 355..375; Helical; 396..416; Helical; 866..886; Helical; 967..987; Helical; 1021..1041; Helical; 1071..1091; Helical; 1102..1122; Helical; 1139..1159; Helical; 1169..1189; Helical; 1207..1227; Helical
Transmembrane Count
15
Ensembl
ENSG00000154265
Entrez Gene Symbol
ABCA5
Gene Synonym
EST90625
Gene Description
ATP binding cassette subfamily A member 5
Chromosome
17
Position
69244311-69327244
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
ABCA5 fluorescence
Tissue Specificadrenal glandCell SpecificEnterocytes
Function & Pathway
Protein Function (3)
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Transporters:Primary Active Transporters
  • Predicted intracellular proteins
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Reactome (3)
Canonical Pathways
M82 Pid ret pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence19

Ligand-Receptor Signaling (18)

18 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
receptorreceptorscConnectYes
transmembranetransmembrane_predictedPhobius
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometryWestern blotting23822545338731868
Sequence, Structure & Domains

Sequences

Length
1,642
Mass
186,508
Sequence
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WWZ7-1; Sequence=Displayed; Name=2; Synonyms=V20+16; IsoId=Q8WWZ7-2; Sequence=VSP_020691, VSP_020692; Name=3; IsoId=Q8WWZ7-3; Sequence=VSP_020690
Alternative Sequence
1..777; Missing (in isoform 3); 922..925; DSDI -> GESV (in isoform 2); 926..1642; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
1259..1268; Acidic residues
Domain (FT)
478..713; ABC transporter 1; 1290..1533; ABC transporter 2
Region
1249..1268; Disordered
Protein Families (2)
  • ABC transporter superfamily
  • ABCA family
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCA family.
Clinical Relevance
Drugs
QUERCETIN-3'-O-PHOSPHATE
Antibody (2)
HPA022032HPA062904
Supporting Publications1
PMIDTitleRelated sentences
38083799Identification of ABCC3 and its isoforms as potential biomarker in hepatocellular carcinoma.Therefore, we analyzed ABCC3 expression in public databases and investigated the presence of ABCC3 and its isoforms in plasma, urine and its release in extracellular vesicles (EVs) cargo from patients bearing cirrhosis and HCC.