Protein detail

PIGB

GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)

Entry name PIGB	UniProt ID Q92521	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 9	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)

Protein Class (4)

Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Transmembrane

63..83; Helical; 136..156; Helical; 192..212; Helical; 224..244; Helical; 255..275; Helical; 315..335; Helical; 340..360; Helical; 362..382; Helical; 387..407; Helical

Transmembrane Count

Ensembl

ENSG00000069943

Entrez Gene Symbol

PIGB

Gene Description

Phosphatidylinositol glycan anchor biosynthesis class B

Chromosome

Position

55318960-55355648

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificEndometrial glandular cells

Function & Pathway7

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ABHD12 AGPAT1 ALG9 ATP13A1 BRI3BP CLCC1 CLN6 CLPTM1L DNAJC16 FADS2 FKBP8 HACD3 HLA-DMB LMF2 PIGB PTDSS1 PTPN1 RHBDD2 SEC61B TCTN2 TMEM43	O95864 P18031 P28068 P48651 P60468 Q14318 Q6NTF9 Q8N2K0 Q8WY22 Q92521 Q96GX1 Q96KA5 Q96S66 Q99943 Q9BTV4 Q9BU23 Q9H6U8 Q9HD20 Q9NWW5 Q9P035 Q9Y2G8	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	5	38731868 24700864 26801919 33709510 41201090

Sequence, Structure & Domains5

Sequences

Length

554

Mass

65,056

Sequence

MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFNMKMKF

Domain & Motif Annotations

Protein Families (2)

Glycosyltransferase 22 family
PIGB subfamily

Sequence Similarities

Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Clinical Relevance2

Disease Involvement

Epilepsy

Antibody

HPA039929

Supporting Publications1

PMID	Title	Abstract
32002171	Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.	No abstract available