Protein detail

PIGB

GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)

Entry name
PIGB
UniProt ID
Q92521
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
9
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins
Basic Information
Protein Names
GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)
Protein Class (4)
Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins
Protein Function (3)
  • Human disease related genes:Nervous system diseases:Epilepsy
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Transmembrane
63..83; Helical; 136..156; Helical; 192..212; Helical; 224..244; Helical; 255..275; Helical; 315..335; Helical; 340..360; Helical; 362..382; Helical; 387..407; Helical
Transmembrane Count
9
Ensembl
ENSG00000069943
Entrez Gene Symbol
PIGB
Gene Description
Phosphatidylinositol glycan anchor biosynthesis class B
Chromosome
15
Position
55318960-55355648
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
PIGB fluorescence
Cell SpecificEndometrial glandular cells
Function & Pathway
Protein Function (3)
  • Human disease related genes:Nervous system diseases:Epilepsy
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (2)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
Page 1 of 2Next

Protein Complex Composition (1)

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blotting53873186824700864268019193370951041201090
Sequence, Structure & Domains

Sequences

Length
554
Mass
65,056
Sequence
MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFNMKMKF

Domain & Motif Annotations

Protein Families (2)
  • Glycosyltransferase 22 family
  • PIGB subfamily
Sequence Similarities
Belongs to the glycosyltransferase 22 family. PIGB subfamily.
Clinical Relevance
Disease Involvement
Epilepsy
Related Diseases
Epilepsy
Antibody
HPA039929
Supporting Publications1
PMIDTitleRelated sentences
32002171Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.No related sentences available