Protein detail

PIGB

GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)

Entry name PIGB	UniProt ID Q92521	EVMP score 0.50
Frequency 1	Transmembrane count 9	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)

Protein Class

Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Transmembrane

63..83; Helical; 136..156; Helical; 192..212; Helical; 224..244; Helical; 255..275; Helical; 315..335; Helical; 340..360; Helical; 362..382; Helical; 387..407; Helical

Transmembrane Count

Ensembl

ENSG00000069943

Entrez Gene Symbol

PIGB

Gene Description

Phosphatidylinositol glycan anchor biosynthesis class B

Chromosome

Position

55318960-55355648

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEndometrial glandular cells

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ABHD12 AGPAT1 ALG9 ATP13A1 BRI3BP CLCC1 CLN6 CLPTM1L DNAJC16 FADS2 FKBP8 HACD3 HLA-DMB LMF2 PIGB PTDSS1 PTPN1 RHBDD2 SEC61B TCTN2 TMEM43	O95864 P18031 P28068 P48651 P60468 Q14318 Q6NTF9 Q8N2K0 Q8WY22 Q92521 Q96GX1 Q96KA5 Q96S66 Q99943 Q9BTV4 Q9BU23 Q9H6U8 Q9HD20 Q9NWW5 Q9P035 Q9Y2G8	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	5	38731868 24700864 26801919 33709510 41201090

Sequence, Structure & Domains

Sequences

Length

554

Mass

65,056

Sequence

MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFNMKMKF

3D Structural Models

Domain & Motif Annotations

Protein Families

Glycosyltransferase 22 family
PIGB subfamily

Sequence Similarities

Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Clinical Relevance

Disease Involvement

Epilepsy

Antibody

HPA039929