Protein detail

SGCD

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Entry name SGCD	UniProt ID Q92629	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

36..56; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000170624

Entrez Gene Symbol

SGCD

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (6)

Biological Process (3)

KEGG (5)

Reactome (3)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
sarcoglycan	matrix_adhesion	Almen2009	No	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
matrix_adhesion	matrix_adhesion	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDEM1 FAM241A SGCD ZACN	Q401N2 Q8N8J7 Q92611 Q92629	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	33936570 38014595

Sequence, Structure & Domains7

Sequences

Length

289

Mass

32,071

Sequence

MPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNALYFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQAGAGSTCQINTSVCL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92629-1; Sequence=Displayed; Name=2; IsoId=Q92629-2; Sequence=VSP_039245; Name=3; IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247

Alternative Sequence

1; M -> MM (in isoform 2 and isoform 3); 233..255; IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG (in isoform 3); 256..289; Missing (in isoform 3)

Domain & Motif Annotations

Protein Families

Sarcoglycan beta/delta/gamma/zeta family

Sequence Similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Clinical Relevance3

Interaction Protein

ENSG00000128591

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available