Protein detail
SGCD
Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)
Entry name SGCD | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
36..56; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (6)
Biological Process (3)
KEGG (5)
Reactome (3)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| sarcoglycan | matrix_adhesion | Almen2009 | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| matrix_adhesion | matrix_adhesion | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes |
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Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
289
Mass
32,071
Sequence
MPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNALYFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQAGAGSTCQINTSVCL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92629-1; Sequence=Displayed; Name=2; IsoId=Q92629-2; Sequence=VSP_039245; Name=3; IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247
Alternative Sequence
1; M -> MM (in isoform 2 and isoform 3); 233..255; IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG (in isoform 3); 256..289; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
Sarcoglycan beta/delta/gamma/zeta family
Sequence Similarities
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Clinical Relevance
Interaction Protein
ENSG00000128591
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |