Protein detail
SGCD
Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)
Entry name SGCD | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
36..56; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization4
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (6)
Biological Process (3)
KEGG (5)
Reactome (3)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Protein Complex Composition (1)
Sequence, Structure & Domains7
Sequences
Length
289
Mass
32,071
Sequence
MPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNALYFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQAGAGSTCQINTSVCL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92629-1; Sequence=Displayed; Name=2; IsoId=Q92629-2; Sequence=VSP_039245; Name=3; IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247
Alternative Sequence
1; M -> MM (in isoform 2 and isoform 3); 233..255; IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG (in isoform 3); 256..289; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
Sarcoglycan beta/delta/gamma/zeta family
Sequence Similarities
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Clinical Relevance3
Interaction Protein
ENSG00000128591
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |