Protein detail

SGCD

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Protein symbol SGCD	UniProt ID Q92629	EVMP score 0.25
Frequency 2	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

36..56; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000170624

Entrez Gene Symbol

SGCD

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDEM1 FAM241A SGCD ZACN	Q401N2 Q8N8J7 Q92611 Q92629	0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	33936570 38014595

Sequence, Structure & Domains

Sequences

Length

289

Mass

32,071

Sequence

MPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNALYFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQAGAGSTCQINTSVCL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92629-1; Sequence=Displayed; Name=2; IsoId=Q92629-2; Sequence=VSP_039245; Name=3; IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247

Alternative Sequence

1; M -> MM (in isoform 2 and isoform 3); 233..255; IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG (in isoform 3); 256..289; Missing (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Protein Families

Sarcoglycan beta/delta/gamma/zeta family

Sequence Similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Clinical Relevance

Interaction Protein

ENSG00000128591

Interaction Count

Interaction Dataset

intact_biogrid