Protein detail

SGCD

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Entry name SGCD	UniProt ID Q92629	EVMP confidence score 0.40
Supporting publications (n) 2	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

36..56; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000170624

Entrez Gene Symbol

SGCD

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (6)

Biological Process (3)

KEGG (5)

Reactome (3)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
cell_surface	cell_surface	OmniPath	Yes
transmembrane	transmembrane_predicted	Phobius	Yes
transmembrane_phobius	transmembrane_predicted	Almen2009	Yes
transmembrane_sosui	transmembrane_predicted	Almen2009	Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009	Yes

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDEM1 FAM241A SGCD ZACN	Q401N2 Q8N8J7 Q92611 Q92629	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	33936570 38014595

Sequence, Structure & Domains

Sequences

Length

289

Mass

32,071

Sequence

MPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMILILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNALYFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVGAERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNMEATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQAGAGSTCQINTSVCL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q92629-1; Sequence=Displayed; Name=2; IsoId=Q92629-2; Sequence=VSP_039245; Name=3; IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247

Alternative Sequence

1; M -> MM (in isoform 2 and isoform 3); 233..255; IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG (in isoform 3); 256..289; Missing (in isoform 3)

Domain & Motif Annotations

Protein Families

Sarcoglycan beta/delta/gamma/zeta family

Sequence Similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Clinical Relevance

Interaction Protein

ENSG00000128591

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No related sentences available