Protein detail
HYAS2
Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)
Entry name HYAS2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)
Protein Function (5)
- Transporters
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Transmembrane
12..32; Helical; Name=1; 46..66; Helical; Name=2; 375..395; Helical; Name=3; 403..423; Helical; Name=4; 430..450; Helical; Name=5; 476..496; Helical; Name=6; 511..531; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
EVMP confidence score
0.38
Fluorescence & Localization1
Tissue Specificesophagus
Function & Pathway6
Protein Function (5)
- Transporters
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence34
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HAS2 | PRKAA2 | P54646 | T | 110 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (28)
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | HPMR | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AAPK2 | P54646 | HYAS2 | Q92819 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21228273PhosphoSite:30394292 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HAS2 hyaluronan biosynthesis complex | HAS2 | Q92819 | 2 | ComplexPortal | intact:EBI-48418541 | 14755292257957792050798526474840 |
| HAS2-HAS3 | HAS2HAS3 | O00219Q92819 | 1:1 | CORUMComplexPortal | intact:EBI-48415993CORUM:7486 | 147552922647484025795779 |
| HAS2HAS3PPATSELENOIUBC | O00219P0CG48Q06203Q92819Q9C0D9 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6002 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 34035220 |
Sequence, Structure & Domains5
Sequences
Length
552
Mass
63,566
Sequence
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
Domain & Motif Annotations
Protein Families
NodC/HAS family
Sequence Similarities
Belongs to the NodC/HAS family.