Protein detail

HYAS2

Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)

Protein symbol HYAS2	UniProt ID Q92819	EVMP score 0.38
Frequency	Transmembrane count 7	Protein classification

Basic Information

Protein Names

Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)

Protein Function

Transporters
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

12..32; Helical; Name=1; 46..66; Helical; Name=2; 375..395; Helical; Name=3; 403..423; Helical; Name=4; 430..450; Helical; Name=5; 476..496; Helical; Name=6; 511..531; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000170961

Entrez Gene Symbol

HAS2

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificesophagus

Function & Pathway

Protein Function

Transporters
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
HAS2	PRKAA2	P54646	T	110	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AAPK2	P54646	HYAS2	Q92819	Yes	No	Yes	PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21228273 PhosphoSite:30394292

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HAS2 hyaluronan biosynthesis complex	HAS2	Q92819	2	ComplexPortal	intact:EBI-48418541	14755292 25795779 20507985 26474840
HAS2-HAS3	HAS2 HAS3	O00219 Q92819	1:1	CORUMComplexPortal	intact:EBI-48415993CORUM:7486	14755292 26474840 25795779
	HAS2 HAS3 PPAT SELENOI UBC	O00219 P0CG48 Q06203 Q92819 Q9C0D9	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6002

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	34035220

Sequence, Structure & Domains

Sequences

Length

552

Mass

63,566

Sequence

MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV

3D Structural Models

Domain & Motif Annotations

Protein Families

NodC/HAS family

Sequence Similarities

Belongs to the NodC/HAS family.

Clinical Relevance