Protein detail

SEM4D

Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)

Protein symbol SEM4D	UniProt ID Q92854	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

735..755; Helical

Transmembrane Count

Ensembl

ENSG00000187764

Entrez Gene Symbol

SEMA4D

Gene Synonym

C9orf164CD100coll-4FLJ39737SEMAJ

Gene Description

Semaphorin 4D

Chromosome

Position

89360787-89498130

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04360 Axon guidance

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
semaphorin	cell_surface_ligand	HGNC	Yes	No	No	Yes	No
semaphorin	cell_surface_ligand	Almen2009	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SEM4D	Q92854	PLXB1	O43157	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:10520995 CellTalkDB:10520995 ICELLNET:11245885 DIP:20877282 Cellinker:24043639 LRdb:10520995 Cellinker:12198496 connectomeDB2020:10520995 connectomeDB2020:11937491 Baccin2019:10520995 LRdb:11937491 Cellinker:27533782 SIGNOR:12198496 Baccin2019:12198496 HPRD:11937491 HPMR:10520995 HINT:20877282 LRdb:12198496 Baccin2019:11937491 connectomeDB2020:12198496 CellChatDB:27533782 IntAct:20877282 Cellinker:11937491

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PlexinC1-SEMA7A complex	PLXNB1 SEMA4D	O43157 Q92854	1:1	CompleatCORUMPDB	PDB:3ol2CORUM:5661Compleat:HC2843	10520995
	CHST3 CRLF1 ECEL1 GNPAT IDUA NDST2 NXPE3 SCGB2A2 SEMA3C SEMA4D VCAM1	O15228 O75462 O95672 P19320 P35475 P52849 Q13296 Q7LGC8 Q92854 Q969Y0 Q99985	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	ECEL1 SCGB2A2 SEMA3C SEMA4D	O95672 Q13296 Q92854 Q99985	0:0:0:0	hu.MAP2
	SEMA4D VCAM1	P19320 Q92854	0:0	hu.MAP2
	SEMA4D	Q92854	2	PDB	PDB:1olz

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	3	38731868 30550287 40311616

Sequence, Structure & Domains

Sequences

Length

862

Mass

96,150

Sequence

MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92854-1; Sequence=Displayed; Name=2; IsoId=Q92854-2; Sequence=VSP_039483, VSP_039484

Alternative Sequence

555..738; DKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMS -> ASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRVSLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAHALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHDRMMQSWRKAWESCSKDTL (in isoform 2); 739..862; Missing (in isoform 2)

3D Structural Models

Turn

34..36; 104..107; 129..131; 140..143; 153..155; 203..205; 349..351; 377..379; 524..527; 532..534; 604..607

Helix

91..99; 284..286; 330..339; 373..376; 383..385; 388..396; 407..409; 503..505; 509..514; 539..541; 550..552; 616..618

Beta Strand

29..32; 40..42; 52..55; 59..65; 67..74; 77..86; 111..117; 119..127; 134..139; 164..169; 172..180; 185..191; 193..195; 210..217; 230..238; 249..257; 264..267; 275..279; 292..299; 308..314; 316..318; 320..329; 342..346; 354..357; 399..404; 412..417; 420..429; 431..433; 435..443; 446..453; 455..465; 475..478; 481..484; 486..490; 495..500; 520..523; 528..531; 553..555; 560..567; 572..574; 584..593; 598..602; 609..611; 620..629; 631..647

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

827..837; Basic and acidic residues

Domain (FT)

22..500; Sema; 502..551; PSI; 554..636; Ig-like C2-type

Region

794..837; Disordered

Protein Families

Semaphorin family

Sequence Similarities

Belongs to the semaphorin family.

Clinical Relevance

Related Diseases

Choreiform disorder Lung cancer Metastatic lymph node neoplasm Multiple sclerosis

Biomarker

Phase 2; Phase 1; Phase 1/2

Drugs

PEPINEMAB NULL

Antibody

HPA015662 HPA023277