Protein detail
SEM4D
Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)
Protein symbol SEM4D | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)
Protein Class
CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- CD markers
- Predicted intracellular proteins
Transmembrane
735..755; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C9orf164CD100coll-4FLJ39737SEMAJ
Gene Description
Semaphorin 4D
Chromosome
9
Position
89360787-89498130
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0004888 transmembrane signaling receptor activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0030215 semaphorin receptor binding
- GO:0038023 signaling receptor activity
- GO:0038191 neuropilin binding
- GO:0042802 identical protein binding
- GO:0045499 chemorepellent activity
- GO:0048018 receptor ligand activity
Biological Process
Reactome
- R-hsa-9675108 nervous system development
- R-hsa-416700 other semaphorin interactions
- R-hsa-416572 sema4d induced cell migration and growth cone collapse
- R-hsa-400685 sema4d in semaphorin signaling
- R-hsa-416550 sema4d mediated inhibition of cell attachment and migration
- R-hsa-373755 semaphorin interactions
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEM4D | Q92854 | PLXB1 | O43157 | Yes | Yes | No | iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:10520995CellTalkDB:10520995ICELLNET:11245885DIP:20877282Cellinker:24043639LRdb:10520995Cellinker:12198496connectomeDB2020:10520995connectomeDB2020:11937491Baccin2019:10520995LRdb:11937491Cellinker:27533782SIGNOR:12198496Baccin2019:12198496HPRD:11937491HPMR:10520995HINT:20877282LRdb:12198496Baccin2019:11937491connectomeDB2020:12198496CellChatDB:27533782IntAct:20877282Cellinker:11937491 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PlexinC1-SEMA7A complex | PLXNB1SEMA4D | O43157Q92854 | 1:1 | CompleatCORUMPDB | PDB:3ol2CORUM:5661Compleat:HC2843 | 10520995 |
| CHST3CRLF1ECEL1GNPATIDUANDST2NXPE3SCGB2A2SEMA3CSEMA4DVCAM1 | O15228O75462O95672P19320P35475P52849Q13296Q7LGC8Q92854Q969Y0Q99985 | 0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| ECEL1SCGB2A2SEMA3CSEMA4D | O95672Q13296Q92854Q99985 | 0:0:0:0 | hu.MAP2 | |||
| SEMA4DVCAM1 | P19320Q92854 | 0:0 | hu.MAP2 | |||
| SEMA4D | Q92854 | 2 | PDB | PDB:1olz |
Sequence, Structure & Domains
Sequences
Length
862
Mass
96,150
Sequence
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92854-1; Sequence=Displayed; Name=2; IsoId=Q92854-2; Sequence=VSP_039483, VSP_039484
Alternative Sequence
555..738; DKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMS -> ASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRVSLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAHALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHDRMMQSWRKAWESCSKDTL (in isoform 2); 739..862; Missing (in isoform 2)
3D Structural Models
Turn
34..36; 104..107; 129..131; 140..143; 153..155; 203..205; 349..351; 377..379; 524..527; 532..534; 604..607
Helix
91..99; 284..286; 330..339; 373..376; 383..385; 388..396; 407..409; 503..505; 509..514; 539..541; 550..552; 616..618
Beta Strand
29..32; 40..42; 52..55; 59..65; 67..74; 77..86; 111..117; 119..127; 134..139; 164..169; 172..180; 185..191; 193..195; 210..217; 230..238; 249..257; 264..267; 275..279; 292..299; 308..314; 316..318; 320..329; 342..346; 354..357; 399..404; 412..417; 420..429; 431..433; 435..443; 446..453; 455..465; 475..478; 481..484; 486..490; 495..500; 520..523; 528..531; 553..555; 560..567; 572..574; 584..593; 598..602; 609..611; 620..629; 631..647
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
827..837; Basic and acidic residues
Domain (FT)
22..500; Sema; 502..551; PSI; 554..636; Ig-like C2-type
Region
794..837; Disordered
Protein Families
Semaphorin family
Sequence Similarities
Belongs to the semaphorin family.
Clinical Relevance
Biomarker
Phase 2; Phase 1; Phase 1/2