Protein detail
LPP
Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)
Entry name LPP | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 18 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (4)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
LIM domain containing preferred translocation partner in lipoma
Chromosome
3
Position
188153284-188890671
Supporting publications (n)
18
EVMP confidence score
0.60
Fluorescence & Localization5
Cell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway5
Protein Function (4)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Disease related genes
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence54
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LPP | SRC | P12931 | Y | 301 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | SRC | P12931 | Y | 244 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | SRC | P12931 | Y | 300 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | EGFR | P00533 | Y | 301 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15951569 |
| LPP | EGF | P01133 | S | 116 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| LPP | IGF1R | P08069 | Y | 300 | phosphorylation | KEA | KEA:17570479 |
| LPP | INSR | P06213 | Y | 301 | phosphorylation | KEA | KEA:17570479 |
| LPP | LCK | P06239 | Y | 301 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | Cellinker | No | Yes | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | LPP | Q93052 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:28436416 |
Protein Complex Composition (28)
28 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30950185 |
Sequence, Structure & Domains8
Sequences
Length
612
Mass
65,746
Sequence
MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
Domain & Motif Annotations
Compositional Bias
26..40; Polar residues; 41..53; Low complexity; 143..158; Polar residues; 171..181; Polar residues; 183..193; Pro residues; 209..219; Polar residues; 314..323; Polar residues
Domain (FT)
414..473; LIM zinc-binding 1; 474..534; LIM zinc-binding 2; 535..603; LIM zinc-binding 3
Region
1..118; Disordered; 132..219; Disordered; 307..387; Disordered
Protein Families
Zyxin/ajuba family
Sequence Similarities
Belongs to the zyxin/ajuba family.
Clinical Relevance5
Supporting Publications18
| PMID | Title | Abstract |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 33441949 | Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma. | No abstract available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 35119778 | Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No abstract available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
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