Protein detail
P2RX5
P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor)
Entry name P2RX5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 2 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
31..51; Helical; Name=1; 320..362; Helical; Name=2
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym
LRH-1P2X5
Gene Description
Purinergic receptor P2X 5
Chromosome
17
Position
3672199-3696240
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Blood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0001614 purinergic nucleotide receptor activity
- GO:0004888 transmembrane signaling receptor activity
- GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
- GO:0005216 monoatomic ion channel activity
- GO:0005524 ATP binding
- GO:0035381 ATP-gated ion channel activity
- GO:0099095 ligand-gated monoatomic anion channel activity
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
444
Mass
49,303
Sequence
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKAGKFSIIPTIINVGSGVALMGAGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=6; IsoId=Q93086-6; Sequence=Displayed; Name=1; IsoId=Q93086-3; Sequence=VSP_062294; Name=2; Synonyms=A; IsoId=Q93086-1; Sequence=VSP_062293, VSP_062294; Name=3; Synonyms=B; IsoId=Q93086-2; Sequence=VSP_062292, VSP_062293, VSP_062294; Name=4; IsoId=Q93086-4; Sequence=VSP_062294, VSP_062295; Name=5; IsoId=Q93086-5; Sequence=VSP_062292, VSP_062294
Alternative Sequence
97..120; Missing (in isoform 3 and isoform 5); 205..206; KS -> N (in isoform 3 and isoform 2); 328..349; Missing (in isoform 1, isoform 2, isoform 3, isoform 4 and isoform 5); 443..444; ST -> LRTPSASPLHQE (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The second transmembrane domain and the conserved Asp-355 are essential for P2RX5 subunit assembly.
Region
378..444; Disordered
Protein Families
P2X receptor family
Sequence Similarities
Belongs to the P2X receptor family.