Protein detail

KISSR

KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)

Protein symbol KISSR	UniProt ID Q969F8	EVMP score 0.50
Frequency 2	Transmembrane count 7	Protein classification Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)

Protein Class

Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Transporters
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Potential drug targets
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Transmembrane

47..67; Helical; Name=1; 79..101; Helical; Name=2; 121..138; Helical; Name=3; 158..178; Helical; Name=4; 203..223; Helical; Name=5; 264..284; Helical; Name=6; 306..328; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000116014

Entrez Gene Symbol

KISS1R

Gene Synonym

AXOR12GPR54HOT7T175

Gene Description

KISS1 receptor

Chromosome

Position

917287-921005

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Transporters
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Potential drug targets
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

57 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
galanin_kisseptin_urotensin_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KISS1	Q15726	KISSR	Q969F8	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Baccin2019:11385580 scConnect:11385580 LRdb:12944565 connectomeDB2020:11385580 LRdb:11457843 CellTalkDB:12944565 connectomeDB2020:12944565 connectomeDB2020:11457843 Guide2Pharma:11457843 Cellinker:12944565 ICELLNET:12944565 Baccin2019:12944565 scConnect:11457843 LRdb:11385580 Baccin2019:15665093 Cellinker:11457843 connectomeDB2020:15665093 Baccin2019:11457843 Cellinker:11385580 Guide2Pharma:11385580 Cellinker:15665093 LRdb:15665093 HPMR:12944565 HPRD:11457843 SIGNOR:11385580
KISSR	Q969F8	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
KISSR	Q969F8	GNAQ	P50148	Yes	Yes	No	KEGG-MEDICUSSIGNOR	SIGNOR:31160049

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	KISS1R	Q969F8	2	PDB	PDB:7yqe

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

398

Mass

42,586

Sequence

MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL

3D Structural Models

Turn

102..104; 324..326

Helix

40..44; 46..69; 71..73; 76..101; 112..145; 149..152; 156..174; 175..180; 198..212; 214..235; 246..287; 299..323; 328..335

Beta Strand

105..107; 181..184; 186..188; 190..193; 242..245; 292..294; 296..298

3D Structure

Electron microscopy (5); X-ray crystallography (1)

Domain & Motif Annotations

Region

341..363; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

Disease variantHypogonadotropic hypogonadism

Related Diseases

Allergic/hypersensitivity disorder Prostate cancer

Biomarker

Terminated; Discontinued in Phase 1

Drugs

BENZETHONIUM CHLORIDE

Antibody

HPA007156 HPA071913

Interaction Protein

ENSG00000113575

Interaction Count

Interaction Dataset

intact_biogrid