Protein detail

KISSR

KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)

Entry name KISSR	UniProt ID Q969F8	EVMP confidence score 0.53
Supporting publications (n) 2	Transmembrane count 7	Protein classification Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)

Protein Class (6)

Disease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (5)

Transporters
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Potential drug targets
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Transmembrane

47..67; Helical; Name=1; 79..101; Helical; Name=2; 121..138; Helical; Name=3; 158..178; Helical; Name=4; 203..223; Helical; Name=5; 264..284; Helical; Name=6; 306..328; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000116014

Entrez Gene Symbol

KISS1R

Gene Synonym (3)

AXOR12GPR54HOT7T175

Gene Description

KISS1 receptor

Chromosome

Position

917287-921005

Supporting publications (n)

EVMP confidence score

0.53

Function & Pathway

Protein Function (5)

Transporters
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Potential drug targets
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence62

Ligand-Receptor Signaling (57)

57 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	LRdb	Yes	Yes
receptor	receptor	Baccin2019	Yes	Yes
gpcr	receptor	Almen2009	Yes	Yes
rhodopsin	receptor	Almen2009	Yes	Yes
gpcr	receptor	UniProt_keyword	Yes	Yes
seven_transmembrane_7tm	receptor	HPMR	Yes	Yes
7tm_a	receptor	HPMR	Yes	Yes
galanin_kisseptin_urotensin_7tm_a	receptor	HPMR	Yes	Yes
rhodopsin	receptor	Surfaceome	Yes	Yes
gpcr	receptor	Surfaceome	Yes	Yes

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
KISS1	Q15726	KISSR	Q969F8	Yes	Yes	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Baccin2019:11385580 scConnect:11385580 LRdb:12944565 connectomeDB2020:11385580 LRdb:11457843 CellTalkDB:12944565 connectomeDB2020:12944565 connectomeDB2020:11457843 Guide2Pharma:11457843 Cellinker:12944565 ICELLNET:12944565 Baccin2019:12944565 scConnect:11457843 LRdb:11385580 Baccin2019:15665093 Cellinker:11457843 connectomeDB2020:15665093 Baccin2019:11457843 Cellinker:11385580 Guide2Pharma:11385580 Cellinker:15665093 LRdb:15665093 HPMR:12944565 HPRD:11457843 SIGNOR:11385580
KISSR	Q969F8	GNA14	O95837	Yes	Yes	SIGNOR	SIGNOR:31160049
KISSR	Q969F8	GNAQ	P50148	Yes	Yes	KEGG-MEDICUSSIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	KISS1R	Q969F8	2	PDB	PDB:7yqe

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

398

Mass

42,586

Sequence

MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL

3D Structural Models

Turn

102..104; 324..326

Helix

40..44; 46..69; 71..73; 76..101; 112..145; 149..152; 156..174; 175..180; 198..212; 214..235; 246..287; 299..323; 328..335

Beta Strand

105..107; 181..184; 186..188; 190..193; 242..245; 292..294; 296..298

3D Structure

Electron microscopy (5); X-ray crystallography (1)

Domain & Motif Annotations

Region

341..363; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement (2)

Disease variantHypogonadotropic hypogonadism

Related Diseases (3)

Hypogonadotropic hypogonadism Allergic/hypersensitivity disorder Prostate cancer

Biomarker

Terminated; Discontinued in Phase 1

Drugs

BENZETHONIUM CHLORIDE

Antibody (2)

HPA007156 HPA071913

Interaction Protein

ENSG00000113575

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Related sentences
30875722	Human Heart Explant-Derived Extracellular Vesicles: Characterization and Effects on the In Vitro Recellularization of Decellularized Heart Valves.	No related sentences available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available