Protein detail
ESAM
Endothelial cell-selective adhesion molecule
Protein symbol ESAM | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Endothelial cell-selective adhesion molecule
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
249..269; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
W117m
Gene Description
Endothelial cell adhesion molecule
Chromosome
11
Position
124752583-124762290
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainCell SpecificTuft cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Cellular Component
Biological Process
KEGG
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| igcam_cxadr_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
390
Mass
41,176
Sequence
MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96AP7-1; Sequence=Displayed; Name=2; IsoId=Q96AP7-2; Sequence=VSP_055594, VSP_055595, VSP_055596
Alternative Sequence
22..200; Missing (in isoform 2); 287..320; EDAIAPRTLPWPKSSDTISKNGTLSSVTSARALR -> VRSPLGLSFSAPKMEWLWKWRDAHFYRDSYLSKW (in isoform 2); 321..390; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
333..342; Polar residues
Domain (FT)
30..143; Ig-like V-type; 153..242; Ig-like C2-type
Region
316..368; Disordered