Protein detail
ESAM
Endothelial cell-selective adhesion molecule
Entry name ESAM | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Endothelial cell-selective adhesion molecule
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
249..269; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
W117m
Gene Description
Endothelial cell adhesion molecule
Chromosome
11
Position
124752583-124762290
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificTuft cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
KEGG (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence39
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | ||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | Yes | ||
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | Yes | ||
| tight_junction | tight_junction | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane_predicted | transmembrane | OmniPath | Yes | ||||
| transmembrane | transmembrane | CellPhoneDB | Yes |
Sequence, Structure & Domains
Sequences
Length
390
Mass
41,176
Sequence
MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96AP7-1; Sequence=Displayed; Name=2; IsoId=Q96AP7-2; Sequence=VSP_055594, VSP_055595, VSP_055596
Alternative Sequence
22..200; Missing (in isoform 2); 287..320; EDAIAPRTLPWPKSSDTISKNGTLSSVTSARALR -> VRSPLGLSFSAPKMEWLWKWRDAHFYRDSYLSKW (in isoform 2); 321..390; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
333..342; Polar residues
Domain (FT)
30..143; Ig-like V-type; 153..242; Ig-like C2-type
Region
316..368; Disordered
Clinical Relevance
Disease Involvement (2)
Disease variantIntellectual disability
Related Diseases
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No related sentences available |
| 37670049 | Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility. | No related sentences available |
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No related sentences available |