Protein detail

TMIG2

Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)

Protein symbol TMIG2	UniProt ID Q96BF3	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

151..171; Helical

Transmembrane Count

Ensembl

ENSG00000167664

Entrez Gene Symbol

TMIGD2

Gene Synonym

CD28HIGPR-1MGC23244

Gene Description

Transmembrane and immunoglobulin domain containing 2

Chromosome

Position

4292227-4302431

Frequency

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0019815 B cell receptor complex

Molecular Function

Biological Process

Mediation Categories

Adhesion and uptake mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TMIGD2	IKBKB	O14920	S	220	phosphorylation	PhosphoSite
TMIGD2	AKT1	P31749	S	220	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
checkpoint	receptor	ICELLNET	No	Yes	No	Yes	No
checkpoint_b7	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AKT1	P31749	TMIG2	Q96BF3	Yes	Yes	No	iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:31341021
IKKB	O14920	TMIG2	Q96BF3	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:28920928 ProtMapper:32978258 SIGNOR:32978258 PhosphoSite:27838321 PhosphoSite:31341021
TMIG2	Q96BF3		COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	Yes	Yes	No	SIGNOR	SIGNOR:32978258

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39778061

Sequence, Structure & Domains

Sequences

Length

282

Mass

30,675

Sequence

MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVCQVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGSMGVAAIVWGAWFWGRRSCQQRDSGNSPGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIYSTSFPQPAPRQPHLASRPCPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVGEE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96BF3-1; Sequence=Displayed; Name=2; IsoId=Q96BF3-2; Sequence=VSP_022967

Alternative Sequence

186..189; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

204..217; Basic and acidic residues; 218..227; Polar residues; 241..253; Pro residues

Domain (FT)

23..129; Ig-like

Region

201..282; Disordered

Clinical Relevance

Antibody

HPA011081