Protein detail
TMIG2
Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
Protein symbol TMIG2 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
Protein Class
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
151..171; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD28HIGPR-1MGC23244
Gene Description
Transmembrane and immunoglobulin domain containing 2
Chromosome
19
Position
4292227-4302431
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AKT1 | P31749 | TMIG2 | Q96BF3 | Yes | Yes | No | iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:31341021 |
| IKKB | O14920 | TMIG2 | Q96BF3 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28920928ProtMapper:32978258SIGNOR:32978258PhosphoSite:27838321PhosphoSite:31341021 |
| TMIG2 | Q96BF3 | COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478 | Yes | Yes | No | SIGNOR | SIGNOR:32978258 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39778061 |
Sequence, Structure & Domains
Sequences
Length
282
Mass
30,675
Sequence
MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVCQVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGSMGVAAIVWGAWFWGRRSCQQRDSGNSPGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIYSTSFPQPAPRQPHLASRPCPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVGEE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96BF3-1; Sequence=Displayed; Name=2; IsoId=Q96BF3-2; Sequence=VSP_022967
Alternative Sequence
186..189; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
204..217; Basic and acidic residues; 218..227; Polar residues; 241..253; Pro residues
Domain (FT)
23..129; Ig-like
Region
201..282; Disordered
Clinical Relevance
Antibody