Protein detail

TMIG2

Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)

Entry name TMIG2	UniProt ID Q96BF3	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

151..171; Helical

Transmembrane Count

Ensembl

ENSG00000167664

Entrez Gene Symbol

TMIGD2

Gene Synonym (3)

CD28HIGPR-1MGC23244

Gene Description

Transmembrane and immunoglobulin domain containing 2

Chromosome

Position

4292227-4302431

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0019815 B cell receptor complex

Molecular Function (2)

Biological Process (3)

Mediation Categories (3)

Adhesion and uptake mediationImmune mediationReceptor-signaling mediation

Relations & Evidence37

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TMIGD2	IKBKB	O14920	S	220	phosphorylation	PhosphoSite
TMIGD2	AKT1	P31749	S	220	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (31)

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AKT1	P31749	TMIG2	Q96BF3	Yes	Yes	No	iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:31341021
IKKB	O14920	TMIG2	Q96BF3	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:28920928 ProtMapper:32978258 SIGNOR:32978258 PhosphoSite:27838321 PhosphoSite:31341021
TMIG2	Q96BF3		COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	Yes	Yes	No	SIGNOR	SIGNOR:32978258

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39778061

Sequence, Structure & Domains8

Sequences

Length

282

Mass

30,675

Sequence

MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVCQVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGSMGVAAIVWGAWFWGRRSCQQRDSGNSPGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIYSTSFPQPAPRQPHLASRPCPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVGEE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96BF3-1; Sequence=Displayed; Name=2; IsoId=Q96BF3-2; Sequence=VSP_022967

Alternative Sequence

186..189; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

204..217; Basic and acidic residues; 218..227; Polar residues; 241..253; Pro residues

Domain (FT)

23..129; Ig-like

Region

201..282; Disordered

Clinical Relevance1

Antibody

HPA011081

Supporting Publications1

PMID	Title	Abstract
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available