Protein detail
SLAF6
SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
Entry name SLAF6 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
Protein Class (2)
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
227..247; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
CD352KALIKALIbLy108NTB-ANTBASF2000
Gene Description
SLAM family member 6
Chromosome
1
Position
160485030-160523262
Supporting publications (n)
4
EVMP confidence score
0.50
Function & Pathway7
Protein Function
CD markers
Cellular Component (3)
Molecular Function
Biological Process (3)
Reactome (2)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence43
Ligand-Receptor Signaling (41)
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryWestern blottingR SequencingSmall R sequencing (Illumi HiSeq 2000)Flow cytometryMORPH | 13 | 34186243330358143816890639409015278941043832153527863537329441933778691834817906289865853095018532089743 |
Sequence, Structure & Domains12
Sequences
Length
332
Mass
37,345
Sequence
MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVSVSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALDNVV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96DU3-1; Sequence=Displayed; Name=2; IsoId=Q96DU3-2; Sequence=VSP_034620; Name=3; IsoId=Q96DU3-3; Sequence=VSP_043230
Alternative Sequence
18..128; Missing (in isoform 3); 266; Missing (in isoform 2)
3D Structural Models
Turn
185..187
Helix
80..83; 101..103; 210..213
Beta Strand
28..33; 38..40; 52..57; 60..66; 69..71; 74..77; 86..88; 94..96; 105..112; 117..127; 131..137; 145..157; 163..168; 171..183; 192..199; 202..209
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
283..288; ITSM 1; 307..312; ITSM 2
Domain (CC)
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain (FT)
35..120; Ig-like V-type; 132..209; Ig-like C2-type
Clinical Relevance2
Drugs
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 29562735 | Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine. | No abstract available |
| 35085587 | Diagnosis of invasive non-functional pituitary adenomas using exosomal biomarkers. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No abstract available |