Protein detail

SLAF6

SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)

Entry name SLAF6	UniProt ID Q96DU3	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification CD markersPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)

Protein Class (2)

CD markersPredicted membrane proteins

Protein Function

CD markers

Transmembrane

227..247; Helical

Transmembrane Count

Ensembl

ENSG00000162739

Entrez Gene Symbol

SLAMF6

Gene Synonym (7)

CD352KALIKALIbLy108NTB-ANTBASF2000

Gene Description

SLAM family member 6

Chromosome

Position

160485030-160523262

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

CD markers

Cellular Component (3)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG

hsa04517 IgSF CAM signaling

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence43

Ligand-Receptor Signaling (41)

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
ligand	ligand	ICELLNET	Yes	No	No	Yes	No
slam	ligand	ICELLNET	Yes	No	No	Yes	No
ligand	ligand	OmniPath	Yes	No	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLAMF6	Q96DU3	4	PDB	PDB:2if7

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingR SequencingSmall R sequencing (Illumi HiSeq 2000)Flow cytometryMORPH	13	34186243 33035814 38168906 39409015 27894104 38321535 27863537 32944193 37786918 34817906 28986585 30950185 32089743

Sequence, Structure & Domains12

Sequences

Length

332

Mass

37,345

Sequence

MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVSVSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALDNVV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96DU3-1; Sequence=Displayed; Name=2; IsoId=Q96DU3-2; Sequence=VSP_034620; Name=3; IsoId=Q96DU3-3; Sequence=VSP_043230

Alternative Sequence

18..128; Missing (in isoform 3); 266; Missing (in isoform 2)

3D Structural Models

Turn

185..187

Helix

80..83; 101..103; 210..213

Beta Strand

28..33; 38..40; 52..57; 60..66; 69..71; 74..77; 86..88; 94..96; 105..112; 117..127; 131..137; 145..157; 163..168; 171..183; 192..199; 202..209

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

283..288; ITSM 1; 307..312; ITSM 2

Domain (CC)

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).

Domain (FT)

35..120; Ig-like V-type; 132..209; Ig-like C2-type

Clinical Relevance2

Drugs

BINETRAKIN

Antibody (2)

HPA051363 HPA051903

Supporting Publications4

PMID	Title	Abstract
29562735	Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine.	No abstract available
35085587	Diagnosis of invasive non-functional pituitary adenomas using exosomal biomarkers.	No abstract available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available
41201090	Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma.	No abstract available