Protein detail

S41A3

Solute carrier family 41 member 3

Entry name S41A3	UniProt ID Q96GZ6	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 10	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier family 41 member 3

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

67..87; Helical; 152..172; Helical; 189..209; Helical; 220..240; Helical; 252..272; Helical; 284..304; Helical; 314..334; Helical; 377..397; Helical; 406..426; Helical; 482..502; Helical

Transmembrane Count

Ensembl

ENSG00000114544

Entrez Gene Symbol

SLC41A3

Gene Synonym

FLJ20473

Gene Description

Solute carrier family 41 member 3

Chromosome

Position

126006357-126101561

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificNeutrophil progenitors

Function & Pathway5

Protein Function

Transporters:Transporter channels and pores

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence20

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC41A3	MAPK8	P45983	S	275	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	12	34186243 39766158 36398564 37786918 34817906 28986585 27894104 30646616 38321535 32089743 29148239 33709510

Sequence, Structure & Domains9

Sequences

Length

507

Mass

54,767

Sequence

MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI

Alternative Products

Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q96GZ6-1; Sequence=Displayed; Name=2; IsoId=Q96GZ6-2; Sequence=VSP_026938; Name=3; IsoId=Q96GZ6-3; Sequence=VSP_026935; Name=4; IsoId=Q96GZ6-4; Sequence=VSP_026935, VSP_026938; Name=5; IsoId=Q96GZ6-5; Sequence=VSP_026934, VSP_026937; Name=6; IsoId=Q96GZ6-6; Sequence=VSP_026936, VSP_026937; Name=7; IsoId=Q96GZ6-7; Sequence=VSP_035505, VSP_035506, VSP_026937; Name=8; IsoId=Q96GZ6-8; Sequence=VSP_043676, VSP_026937; Name=9; IsoId=Q96GZ6-9; Sequence=VSP_054059, VSP_054060

Alternative Sequence

1..117; Missing (in isoform 8); 1..26; Missing (in isoform 7); 27..90; STGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYF -> MVVTQLNLEFCFQGKKLRGFSCELTRSPHGVLPESFFTIMCQVVVPILLSGLCMMTAGLVMNTI (in isoform 7); 61..69; Missing (in isoform 5); 92..127; Missing (in isoform 3 and isoform 4); 218..266; Missing (in isoform 6); 457..507; SSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI -> TGLLALCFFTDWLLKSKAELGGISELASGPP (in isoform 5, isoform 6, isoform 7 and isoform 8); 457..487; SSSVGHTAAVPRRCTASPGWGLIQPFICTQH -> TGLLALCFFTDWLLKSKAELGGISELASGPP (in isoform 9); 488..507; Missing (in isoform 9); 501..507; Missing (in isoform 2 and isoform 4)

Domain & Motif Annotations

Compositional Bias

1..13; Basic and acidic residues

Region

1..60; Disordered

Protein Families

SLC41A transporter family

Sequence Similarities

Belongs to the SLC41A transporter family.

Clinical Relevance1

Antibody

HPA045847

Supporting Publications2

PMID	Title	Abstract
37403840	Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma.	No abstract available
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available