Protein detail
MEG10
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Entry name MEG10 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
858..878; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.40
Function & Pathway
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence40
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MEGF10 | SRC | P12931 | Y | 1,030 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Surfaceome | Yes | Yes | Yes | ||
| scavenger | receptor | Almen2009 | Yes | Yes | Yes | ||
| scar | receptor | Surfaceome | Yes | Yes | Yes | ||
| class_f | receptor | Surfaceome | Yes | Yes | Yes | ||
| receptor | receptor | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | |
| transmembrane | transmembrane | UniProt_location | Yes | Yes |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABCA1 | O95477 | MEG10 | Q96KG7 | Yes | Yes | SIGNOR | SIGNOR:17205124 | |
| MEG10 | Q96KG7 | ABCA1 | O95477 | Yes | Yes | CellTalkDBSIGNOR | CellTalkDB:17205124SIGNOR:17205124 | |
| SRC | P12931 | MEG10 | Q96KG7 | Yes | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28498977SIGNOR:23954233PhosphoSite:23954233 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34265469 |
Sequence, Structure & Domains
Sequences
Length
1,140
Mass
122,205
Sequence
MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96KG7-1; Sequence=Displayed; Name=2; IsoId=Q96KG7-2; Sequence=VSP_029244, VSP_029245
Alternative Sequence
566..567; VH -> LF (in isoform 2); 568..1140; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1128..1140; Low complexity
Domain (CC)
The EMI and EGF-like domains work in concert to promote self-assembly.
Domain (FT)
30..107; EMI; 106..136; EGF-like 1; 144..179; EGF-like 2; 187..222; EGF-like 3; 230..265; EGF-like 4; 278..308; EGF-like 5; 316..351; EGF-like 6; 405..440; EGF-like 7; 453..483; EGF-like 8; 491..526; EGF-like 9; 539..569; EGF-like 10; 577..612; EGF-like 11; 665..700; EGF-like 12; 713..743; EGF-like 13; 751..786; EGF-like 14; 799..829; EGF-like 15
Region
1..857; Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern; 945..1140; Necessary for formation of large intracellular vacuoles; 1111..1140; Disordered
Protein Families
MEGF family
Sequence Similarities
Belongs to the MEGF family.
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No related sentences available |
| 32944193 | Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. | No related sentences available |