Protein detail
MEG10
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Protein symbol MEG10 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
858..878; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MEGF10 | SRC | P12931 | Y | 1,030 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| basolateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABCA1 | O95477 | MEG10 | Q96KG7 | Yes | Yes | No | SIGNOR | SIGNOR:17205124 |
| MEG10 | Q96KG7 | ABCA1 | O95477 | Yes | Yes | No | CellTalkDBSIGNOR | CellTalkDB:17205124SIGNOR:17205124 |
| SRC | P12931 | MEG10 | Q96KG7 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28498977SIGNOR:23954233PhosphoSite:23954233 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34265469 |
Sequence, Structure & Domains
Sequences
Length
1,140
Mass
122,205
Sequence
MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96KG7-1; Sequence=Displayed; Name=2; IsoId=Q96KG7-2; Sequence=VSP_029244, VSP_029245
Alternative Sequence
566..567; VH -> LF (in isoform 2); 568..1140; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1128..1140; Low complexity
Domain (CC)
The EMI and EGF-like domains work in concert to promote self-assembly.
Domain (FT)
30..107; EMI; 106..136; EGF-like 1; 144..179; EGF-like 2; 187..222; EGF-like 3; 230..265; EGF-like 4; 278..308; EGF-like 5; 316..351; EGF-like 6; 405..440; EGF-like 7; 453..483; EGF-like 8; 491..526; EGF-like 9; 539..569; EGF-like 10; 577..612; EGF-like 11; 665..700; EGF-like 12; 713..743; EGF-like 13; 751..786; EGF-like 14; 799..829; EGF-like 15
Region
1..857; Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern; 945..1140; Necessary for formation of large intracellular vacuoles; 1111..1140; Disordered
Protein Families
MEGF family
Sequence Similarities
Belongs to the MEGF family.