Protein detail
KCNH8
Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1)
Entry name KCNH8 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 6 | Protein classification Predicted membrane proteinsVoltage-gated ion channels |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1)
Protein Class (2)
Predicted membrane proteinsVoltage-gated ion channels
Protein Function
Voltage-gated ion channels:Voltage-Gated Potassium Channels
Transmembrane
226..246; Helical; Name=Segment S1; 256..276; Helical; Name=Segment S2; 299..319; Helical; Name=Segment S3; 328..348; Helical; Voltage-sensor; Name=Segment S4; 358..378; Helical; Name=Segment S5; 449..469; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
elk3Kv12.1
Gene Description
Potassium voltage-gated channel subfamily H member 8
Chromosome
3
Position
19148510-19535642
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function
Voltage-gated ion channels:Voltage-Gated Potassium Channels
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence18
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Sequence, Structure & Domains11
Sequences
Length
1,107
Mass
123,804
Sequence
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASASTKPLENLPLEVVTSTAEVKDNKAINV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96L42-1; Sequence=Displayed; Name=2; IsoId=Q96L42-2; Sequence=VSP_057036, VSP_057037, VSP_057038, VSP_057039
Alternative Sequence
1..359; Missing (in isoform 2); 459; A -> VSQFQVCPRPSWIICWFRNHFGFILLMTT (in isoform 2); 515..516; WS -> CF (in isoform 2); 517..1107; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
686..702; Polar residues; 710..724; Acidic residues; 961..972; Polar residues
Motif
434..439; Selectivity filter
Domain (FT)
18..90; PAS; 93..145; PAC
Region
551..668; cNMP-binding domain; 686..742; Disordered; 764..791; Disordered; 818..847; Disordered; 961..989; Disordered
Protein Families (3)
- Potassium channel family
- H (Eag) (TC 1.A.1.20) subfamily
- Kv12.1/KCNH8 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.
Clinical Relevance3
Drug Targets
Literature-reported target
Drugs (6)