Protein detail
APLD1
Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein)
Entry name APLD1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 3 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein)
Protein Class
Predicted membrane proteins
Transmembrane
83..105; Helical; 122..142; Helical; 192..212; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DKFZP434F0318FLJ25138
Gene Description
Apolipoprotein L domain containing 1
Chromosome
12
Position
12725917-12829975
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificEsophageal apical cellsBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway4
Cellular Component (5)
Molecular Function
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationMicrofluidics-Based Methods | Mass spectrometry | 1 | 41167904 |
Sequence, Structure & Domains8
Sequences
Length
279
Mass
30,546
Sequence
MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAREPHGPDALRRFQGLLLDRRGRLHGQVLRLREVARRLERLRRRSLVANVAGSSLSATGALAAIVGLSLSPVTLGTSLLVSAVGLGVATAGGAVTITSDLSLIFCNSRELRRVQEIAATCQDQMREILSCLEFFCRWQGCGDRQLLQCGRNASIALYNSVYFIVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAESLESCTGALDELSEQLESRVQLCTKSSRGHDLKISADQRAGLFF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LR9-1; Sequence=Displayed; Name=2; IsoId=Q96LR9-2; Sequence=VSP_019960
Alternative Sequence
2..32; Missing (in isoform 2)
Domain & Motif Annotations
Coiled Coil
226..253
Protein Families
Apolipoprotein L family
Sequence Similarities
Belongs to the apolipoprotein L family.
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |