Protein detail
PCFT
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Entry name PCFT | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification Disease related genesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Protein Class
Disease related genesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
26..44; Helical; Name=TM1; 83..108; Helical; Name=TM2; 113..135; Helical; Name=TM3; 141..154; Helical; Name=TM4; 178..203; Helical; Name=TM5; 209..227; Helical; Name=TM6; 267..289; Helical; Name=TM7; 303..325; Helical; Name=TM8; 332..351; Helical; Name=TM9; 356..376; Helical; Name=TM10; 389..414; Helical; Name=TM11; 423..441; Helical; Name=TM12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
HCP1hPCFTHsPCFTMGC9564PCFT
Gene Description
Solute carrier family 46 member 1
Chromosome
17
Position
28394642-28407197
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component
Molecular Function
- GO:0005542 folic acid binding
- GO:0008517 folic acid transmembrane transporter activity
- GO:0015078 proton transmembrane transporter activity
- GO:0015232 heme transmembrane transporter activity
- GO:0015293 symporter activity
- GO:0015350 methotrexate transmembrane transporter activity
- GO:0022857 transmembrane transporter activity
- GO:0140211 folic acid:proton symporter activity
Biological Process
KEGG
Reactome
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9707616 heme signaling
- R-hsa-917937 iron uptake and transport
- R-hsa-196757 metabolism of folate and pterines
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34265469 |
Sequence, Structure & Domains
Sequences
Length
459
Mass
49,771
Sequence
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NT5-1; Sequence=Displayed; Name=2; IsoId=Q96NT5-2; Sequence=VSP_016053
Alternative Sequence
361..388; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
- Major facilitator superfamily
- SLC46A family
Sequence Similarities
Belongs to the major facilitator superfamily. SLC46A family.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Approved; Investigative; Phase 1; Phase 3
Drug Targets
Successful target
Antibody