Protein detail
PCFT
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Entry name PCFT | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Disease related genesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Protein Class (8)
Disease related genesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
26..44; Helical; Name=TM1; 83..108; Helical; Name=TM2; 113..135; Helical; Name=TM3; 141..154; Helical; Name=TM4; 178..203; Helical; Name=TM5; 209..227; Helical; Name=TM6; 267..289; Helical; Name=TM7; 303..325; Helical; Name=TM8; 332..351; Helical; Name=TM9; 356..376; Helical; Name=TM10; 389..414; Helical; Name=TM11; 423..441; Helical; Name=TM12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
HCP1hPCFTHsPCFTMGC9564PCFT
Gene Description
Solute carrier family 46 member 1
Chromosome
17
Position
28394642-28407197
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificAdrenal medulla cells
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component (8)
Molecular Function (8)
- GO:0005542 folic acid binding
- GO:0008517 folic acid transmembrane transporter activity
- GO:0015078 proton transmembrane transporter activity
- GO:0015232 heme transmembrane transporter activity
- GO:0015293 symporter activity
- GO:0015350 methotrexate transmembrane transporter activity
- GO:0022857 transmembrane transporter activity
- GO:0140211 folic acid:proton symporter activity
Biological Process (3)
KEGG (5)
Reactome (7)
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9707616 heme signaling
- R-hsa-917937 iron uptake and transport
- R-hsa-196757 metabolism of folate and pterines
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-382551 transport of small molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence31
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| apical_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34265469 |
Sequence, Structure & Domains7
Sequences
Length
459
Mass
49,771
Sequence
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NT5-1; Sequence=Displayed; Name=2; IsoId=Q96NT5-2; Sequence=VSP_016053
Alternative Sequence
361..388; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families (2)
- Major facilitator superfamily
- SLC46A family
Sequence Similarities
Belongs to the major facilitator superfamily. SLC46A family.
Clinical Relevance6
Disease Involvement
Disease variant
Related Diseases (7)
Biomarker
Approved; Investigative; Phase 1; Phase 3
Drug Targets
Successful target
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34771645 | GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer. | No abstract available |