Protein detail

FCRL3

Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)

Protein symbol FCRL3	UniProt ID Q96P31	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification CD markersDisease related genesPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Protein Class

CD markersDisease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Disease related genes
CD markers
Predicted intracellular proteins

Transmembrane

574..594; Helical

Transmembrane Count

Ensembl

ENSG00000160856

Entrez Gene Symbol

FCRL3

Gene Synonym

CD307cFCRH3IFGP3IRTA3SPAP2SPAP2aSPAP2bSPAP2cSPAP2dSPAP2e

Gene Description

Fc receptor like 3

Chromosome

Position

157674321-157700769

Frequency

EVMP Score

0.25

Fluorescence & Localization

Brain Regional Specificcerebral cortexCell SpecificAdrenal medulla cellsSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway

Protein Function

Disease related genes
CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
FCRL3	SRC	P12931	Y	722	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
FCRL3	SRC	P12931	Y	662	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
FCRL3	SRC	P12931	Y	692	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
FCRL3	SRC	P12931	Y	650	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
fc	receptor	Almen2009	No	Yes	No	Yes	No
ig_like	receptor	Almen2009	No	Yes	No	Yes	No
fcr	receptor	Surfaceome	No	Yes	No	Yes	No
ig	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	FCRL3	Q96P31	Yes	Yes	No	PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:12051764 SIGNOR:12051764
FCRL3	Q96P31	PTN6	P29350	Yes	Yes	No	SIGNOR	SIGNOR:12051764
FCRL3	Q96P31	ZAP70	P43403	Yes	Yes	No	HPRDNetPathSIGNOR	HPRD:12051764 NetPath:12051764 SIGNOR:12051764
FCRL3	Q96P31	PTN11	Q06124	Yes	Yes	No	SIGNOR	SIGNOR:12051764
FCRL3	Q96P31	KSYK	P43405	Yes	Yes	No	SIGNOR	SIGNOR:12051764

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Small R sequencing (Illumi HiSeq 2000 (Solexa)	1	22329422

Sequence, Structure & Domains

Sequences

Length

734

Mass

80,856

Sequence

MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=Spap2a; IsoId=Q96P31-1; Sequence=Displayed; Name=2; Synonyms=Spap2b; IsoId=Q96P31-2; Sequence=VSP_033300; Name=3; Synonyms=Spap2c; IsoId=Q96P31-3; Sequence=VSP_033305; Name=4; Synonyms=Spap2d; IsoId=Q96P31-4; Sequence=VSP_033301, VSP_033303; Name=5; IsoId=Q96P31-5; Sequence=VSP_033302, VSP_033304; Name=6; IsoId=Q96P31-6; Sequence=VSP_033308; Name=7; IsoId=Q96P31-7; Sequence=VSP_033306, VSP_033307

Alternative Sequence

187..282; ELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQR -> G (in isoform 2); 187..189; ELF -> GNG (in isoform 4); 188..199; LFLHPVLRASSS -> ARCPAAILPLQR (in isoform 5); 190..734; Missing (in isoform 4); 200..734; Missing (in isoform 5); 378; I -> TLLSPSV (in isoform 3); 698..707; THPDDSAGEA -> EQSSRFSMSL (in isoform 7); 708..734; Missing (in isoform 7); 725..734; VPRVLLASDH -> ILNPRKNKVQDFPCLCNT (in isoform 6)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

608..627; Polar residues; 628..637; Basic and acidic residues

Motif

648..653; ITIM motif 1; 660..665; ITIM motif 2; 690..695; ITIM motif 3; 720..725; ITIM motif 4

Domain (FT)

21..98; Ig-like C2-type 1; 99..182; Ig-like C2-type 2; 192..270; Ig-like C2-type 3; 284..369; Ig-like C2-type 4; 383..470; Ig-like C2-type 5; 476..563; Ig-like C2-type 6

Region

603..655; Disordered; 695..734; Disordered

Clinical Relevance

Antibody

HPA048022