Protein detail
PANX2
Pannexin-2
Entry name PANX2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Pannexin-2
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
48..70; Helical; 124..146; Helical; 227..249; Helical; 293..315; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
hPANX2PX2
Gene Description
Pannexin 2
Chromosome
22
Position
50170731-50180295
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Biological Process
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PANX2 | STK38 | Q15208 | S | 514 | phosphorylation | SIGNOR | SIGNOR:22445341 |
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| pannexin | transporter | HGNC | No | Yes | No | No | No |
| transporter | transporter | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STK38 | Q15208 | PANX2 | Q96RD6 | Yes | Yes | No | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:22445341SIGNOR:22445341 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Size Exclusion Chromatography | Flow cytometryMORPH | 1 | 41216884 |
Sequence, Structure & Domains
Sequences
Length
677
Mass
74,447
Sequence
MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q96RD6-3; Sequence=Displayed; Name=1; IsoId=Q96RD6-1; Sequence=VSP_002677; Name=2; IsoId=Q96RD6-2; Sequence=VSP_039092, VSP_002677
Alternative Sequence
1..134; Missing (in isoform 2); 632..677; YEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF -> SSSPPSTSRERS (in isoform 1 and isoform 2)
3D Structural Models
Turn
389..391
Helix
49..75; 89..101; 119..182; 190..201; 205..218; 222..250; 284..313; 320..328; 334..336; 343..353; 355..357; 359..366; 369..371; 373..375; 379..388
Beta Strand
108..110; 112..114; 256..260; 268..270; 276..280
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Compositional Bias
492..504; Pro residues
Region
393..423; Disordered; 454..510; Disordered
Protein Families
Pannexin family
Sequence Similarities
Belongs to the pannexin family.