Protein detail

PANX2

Pannexin-2

Entry name PANX2	UniProt ID Q96RD6	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

Basic Information

Protein Names

Pannexin-2

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

48..70; Helical; 124..146; Helical; 227..249; Helical; 293..315; Helical

Transmembrane Count

Ensembl

ENSG00000073150

Entrez Gene Symbol

PANX2

Gene Synonym (2)

hPANX2PX2

Gene Description

Pannexin 2

Chromosome

Position

50170731-50180295

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence30

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PANX2	STK38	Q15208	S	514	phosphorylation	SIGNOR	SIGNOR:22445341

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver
ion_channel	ion_channel	OmniPath		Yes
gap_junction	gap_junction	Ramilowski_location	Yes	Yes
pannexin	gap_junction	HGNC	Yes	Yes
gap_junction	gap_junction	OmniPath	Yes	Yes
transmembrane	transmembrane	UniProt_location
transmembrane	transmembrane	UniProt_topology
transmembrane	transmembrane	UniProt_keyword
transmembrane	transmembrane	TopDB
transmembrane	transmembrane	Ramilowski_location
transmembrane	transmembrane	OmniPath

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STK38	Q15208	PANX2	Q96RD6	Yes	Yes		SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:22445341 SIGNOR:22445341

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PANX2	Q96RD6	7	PDB	PDB:7xlbPDB:8gyq

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Size Exclusion Chromatography	Flow cytometryMORPH	1	41216884

Sequence, Structure & Domains

Sequences

Length

677

Mass

74,447

Sequence

MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q96RD6-3; Sequence=Displayed; Name=1; IsoId=Q96RD6-1; Sequence=VSP_002677; Name=2; IsoId=Q96RD6-2; Sequence=VSP_039092, VSP_002677

Alternative Sequence

1..134; Missing (in isoform 2); 632..677; YEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF -> SSSPPSTSRERS (in isoform 1 and isoform 2)

3D Structural Models

Turn

389..391

Helix

49..75; 89..101; 119..182; 190..201; 205..218; 222..250; 284..313; 320..328; 334..336; 343..353; 355..357; 359..366; 369..371; 373..375; 379..388

Beta Strand

108..110; 112..114; 256..260; 268..270; 276..280

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

492..504; Pro residues

Region

393..423; Disordered; 454..510; Disordered

Protein Families

Pannexin family

Sequence Similarities

Belongs to the pannexin family.

Clinical Relevance

Drugs (2)

FLUFENAMIC ACID CARBENOXOLONE

Antibody (2)

HPA004624 HPA039117

Supporting Publications1

PMID	Title	Related sentences
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No related sentences available