Protein detail
SERC2
Serine incorporator 2 (Tumor differentially expressed protein 2-like)
Entry name SERC2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 11 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Serine incorporator 2 (Tumor differentially expressed protein 2-like)
Protein Class
Predicted membrane proteins
Transmembrane
5..27; Helical; 40..57; Helical; 96..118; Helical; 131..150; Helical; 160..182; Helical; 202..224; Helical; 239..256; Helical; 268..290; Helical; 317..339; Helical; 385..407; Helical; 422..444; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FKSG84PRO0899TDE2TDE2L
Gene Description
Serine incorporator 2
Chromosome
1
Position
31409565-31434680
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway4
Cellular Component (2)
Biological Process (3)
Mediation Categories
Metabolism mediation
Relations & Evidence14
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 34265469 |
Sequence, Structure & Domains7
Sequences
Length
455
Mass
50,742
Sequence
MGACLGACSLLSCASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAPLLLRNRDFS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96SA4-1; Sequence=Displayed; Name=2; IsoId=Q96SA4-2; Sequence=VSP_042464; Name=3; IsoId=Q96SA4-3; Sequence=VSP_042463; Name=4; IsoId=Q96SA4-4; Sequence=VSP_046840
Alternative Sequence
1..13; MGACLGACSLLSC -> MRSMRLREEESPGPSHT (in isoform 3); 1..13; MGACLGACSLLSC -> MDGRMMRSMRLREEESPGPSHT (in isoform 4); 4..13; CLGACSLLSC -> EGAPDFLSCPRVRR (in isoform 2)
Domain & Motif Annotations
Protein Families
TDE1 family
Sequence Similarities
Belongs to the TDE1 family.
Clinical Relevance1
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |