Protein detail
KCNKH
Potassium channel subfamily K member 17 (2P domain potassium channel Talk-2) (Acid-sensitive potassium channel protein TASK-4) (TWIK-related acid-sensitive K(+) channel 4) (TWIK-related alkaline pH-activated K(+) channel 2) (TALK-2)
Protein symbol KCNKH | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Potassium channel subfamily K member 17 (2P domain potassium channel Talk-2) (Acid-sensitive potassium channel protein TASK-4) (TWIK-related acid-sensitive K(+) channel 4) (TWIK-related alkaline pH-activated K(+) channel 2) (TALK-2)
Protein Class
Predicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Voltage-gated ion channels:Two-P Potassium Channels
- Transporters:Transporter channels and pores
Transmembrane
21..43; Helical; 128..148; Helical; 180..200; Helical; 244..264; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
K2p17.1TALK-2TALK2TASK-4TASK4
Gene Description
Potassium two pore domain channel subfamily K member 17
Chromosome
6
Position
39299001-39314461
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function
- Voltage-gated ion channels:Two-P Potassium Channels
- Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
332
Mass
36,895
Sequence
MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96T54-3; Sequence=Displayed; Name=2; IsoId=Q96T54-4; Sequence=VSP_047354
Alternative Sequence
230..332; GMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS -> ASCLISDTRKPNRDWQTLERTSKSSGGLLKYRFLAGHGGSHL (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The pore-forming domains 1 and 2 assemble to form a single pore in which M2 and M4 transmembrane helices line the central cavity and M1 and M3 face the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 carrying a signature sequence TxTTxGYGD that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.
Region
116..121; Selectivity filter 1; 221..226; Selectivity filter 2; 287..312; Disordered
Protein Families
Two pore domain potassium channel (TC 1.A.1.8) family
Sequence Similarities
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Clinical Relevance
Antibody