Protein detail
NIBA2
Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)
Entry name NIBA2 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 13 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (8)
bA356B19.6C9orf88DKFZP434H0820FAM129BFLJ13518FLJ22151FLJ22298MINERVA
Gene Description
Niban apoptosis regulator 2
Chromosome
9
Position
127505339-127578989
Supporting publications (n)
13
EVMP confidence score
0.72
Fluorescence & Localization1
Cell SpecificAstrocytes
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence12
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NIBAN2 | EGFR | P00533 | Y | 593 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| NIBAN2 | EGF | P01133 | S | 624 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BRAF | P15056 | NIBA2 | Q96TA1 | Yes | No | Yes | SIGNOR | SIGNOR:33684228 |
| NIBA2 | Q96TA1 | RASH | P01112 | Yes | Yes | No | SIGNOR | SIGNOR:26721396 |
| EGFR | P00533 | NIBA2 | Q96TA1 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26721396ProtMapper:27111472ProtMapper:31262713SIGNOR:26721396 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains14
Sequences
Length
746
Mass
84,138
Sequence
MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSAGVQTEF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96TA1-1; Sequence=Displayed; Name=2; IsoId=Q96TA1-2; Sequence=VSP_041810
Alternative Sequence
1..18; MGDVLSTHLDDARRQHIA -> MGWMG (in isoform 2)
3D Structural Models
Turn
80..82; 140..143; 399..402; 513..515; 528..530; 557..559
Helix
4..8; 11..49; 104..108; 128..135; 177..195; 205..219; 233..253; 254..256; 261..338; 340..342; 343..379; 385..392; 393..397; 403..406; 407..411; 423..456; 465..512; 516..522; 525..527; 533..556
Beta Strand
71..78; 85..92; 98..102; 114..117; 123..127; 155..163; 165..167; 170..176; 419..421
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
671..693; Low complexity; 720..746; Polar residues
Domain (FT)
68..192; PH
Region
590..746; Disordered
Protein Families
Niban family
Sequence Similarities
Belongs to the Niban family.
Clinical Relevance4
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 32916986 | Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines. | No abstract available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38891077 | Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No abstract available |
Page 1 of 2Next