Protein detail
NIBA2
Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)
Protein symbol NIBA2 | UniProt ID | EVMP score 0.72 |
Frequency 13 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
bA356B19.6C9orf88DKFZP434H0820FAM129BFLJ13518FLJ22151FLJ22298MINERVA
Gene Description
Niban apoptosis regulator 2
Chromosome
9
Position
127505339-127578989
Frequency
13
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NIBAN2 | EGFR | P00533 | Y | 593 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| NIBAN2 | EGF | P01133 | S | 624 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BRAF | P15056 | NIBA2 | Q96TA1 | Yes | No | Yes | SIGNOR | SIGNOR:33684228 |
| NIBA2 | Q96TA1 | RASH | P01112 | Yes | Yes | No | SIGNOR | SIGNOR:26721396 |
| EGFR | P00533 | NIBA2 | Q96TA1 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26721396ProtMapper:27111472ProtMapper:31262713SIGNOR:26721396 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
746
Mass
84,138
Sequence
MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSAGVQTEF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96TA1-1; Sequence=Displayed; Name=2; IsoId=Q96TA1-2; Sequence=VSP_041810
Alternative Sequence
1..18; MGDVLSTHLDDARRQHIA -> MGWMG (in isoform 2)
3D Structural Models
Turn
80..82; 140..143; 399..402; 513..515; 528..530; 557..559
Helix
4..8; 11..49; 104..108; 128..135; 177..195; 205..219; 233..253; 254..256; 261..338; 340..342; 343..379; 385..392; 393..397; 403..406; 407..411; 423..456; 465..512; 516..522; 525..527; 533..556
Beta Strand
71..78; 85..92; 98..102; 114..117; 123..127; 155..163; 165..167; 170..176; 419..421
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
671..693; Low complexity; 720..746; Polar residues
Domain (FT)
68..192; PH
Region
590..746; Disordered
Protein Families
Niban family
Sequence Similarities
Belongs to the Niban family.