Protein detail

NIBA2

Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)

Entry name NIBA2	UniProt ID Q96TA1	EVMP confidence score 0.72
Supporting publications (n) 13	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000136830

Entrez Gene Symbol

NIBAN2

Gene Synonym (8)

bA356B19.6C9orf88DKFZP434H0820FAM129BFLJ13518FLJ22151FLJ22298MINERVA

Gene Description

Niban apoptosis regulator 2

Chromosome

Position

127505339-127578989

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization1

Cell SpecificAstrocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence12

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NIBAN2	EGFR	P00533	Y	593	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
NIBAN2	EGF	P01133	S	624	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BRAF	P15056	NIBA2	Q96TA1	Yes	No	Yes	SIGNOR	SIGNOR:33684228
NIBA2	Q96TA1	RASH	P01112	Yes	Yes	No	SIGNOR	SIGNOR:26721396
EGFR	P00533	NIBA2	Q96TA1	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:26721396 ProtMapper:27111472 ProtMapper:31262713 SIGNOR:26721396

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AP3D1 HTATSF1 KATNAL2 NAF1 NIBAN2	O14617 O43719 Q8IYT4 Q96HR8 Q96TA1	0:0:0:0:0	Havugimana2012	Havugimana2012:C_435
	CDK15 NIBAN2 PLA2G4E SDR16C5	Q3MJ16 Q8N3Y7 Q96Q40 Q96TA1	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38716512

Sequence, Structure & Domains14

Sequences

Length

746

Mass

84,138

Sequence

MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSAGVQTEF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96TA1-1; Sequence=Displayed; Name=2; IsoId=Q96TA1-2; Sequence=VSP_041810

Alternative Sequence

1..18; MGDVLSTHLDDARRQHIA -> MGWMG (in isoform 2)

3D Structural Models

Turn

80..82; 140..143; 399..402; 513..515; 528..530; 557..559

Helix

4..8; 11..49; 104..108; 128..135; 177..195; 205..219; 233..253; 254..256; 261..338; 340..342; 343..379; 385..392; 393..397; 403..406; 407..411; 423..456; 465..512; 516..522; 525..527; 533..556

Beta Strand

71..78; 85..92; 98..102; 114..117; 123..127; 155..163; 165..167; 170..176; 419..421

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

671..693; Low complexity; 720..746; Polar residues

Domain (FT)

68..192; PH

Region

590..746; Disordered

Protein Families

Niban family

Sequence Similarities

Belongs to the Niban family.

Clinical Relevance4

Antibody (4)

HPA021284 HPA021417 HPA023261 HPA024312

Interaction Protein

ENSG00000079999

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications13

PMID	Title	Abstract
40985879	TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available

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