Protein detail

CYH2

Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)

Protein symbol CYH2	UniProt ID Q99418	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000105443

Entrez Gene Symbol

CYTH2

Gene Synonym

ARNOCTS18.1cytohesin-2PSCD2PSCD2LSec7p-LSec7p-like

Gene Description

Cytohesin 2

Chromosome

Position

48469208-48482314

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificAdipocytesSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

9 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CYTH2	PRKCA	P17252	S	392	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:10531036 phosphoELM:10531036 KEA:10531036 HPRD:10531036 KEA:17570479 ProtMapper:10531036
CYTH2	PRKCA	P17252	S	391	phosphorylation	HPRDKEA	HPRD:10531036 KEA:10531036
CYTH2	PRKCG	P05129	S	392	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:10531036 ProtMapper:10531036 HPRD:10531036 KEA:10531036
CYTH2	PRKCG	P05129	S	391	phosphorylation	HPRDKEA	HPRD:10531036 KEA:10531036
CYTH2	PRKCB	P05771	S	392	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:10531036 ProtMapper:10531036 HPRD:10531036 KEA:10531036
CYTH2	PRKCB	P05771	S	391	phosphorylation	HPRDKEA	HPRD:10531036 KEA:10531036
CYTH2	AKT1	P31749	T	276	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
CYTH2	PRKCD	Q05655	S	392	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CYTH2	PRKCE	Q02156	S	392	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCA	P17252	CYH2	Q99418	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteAdhesomeHPRD-phos	Adhesome:10531036 PhosphoSite:10531036 SIGNOR:10531036 phosphoELM:10531036 PhosphoSite:18042453 KEA:10531036 PhosphoSite:24303080 PhosphoSite:24083777 HPRD-phos:10531036 HPRD:10531036 KEA:17570479 ProtMapper:10531036 PhosphoSite:20153292
KPCB	P05771	CYH2	Q99418	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	SIGNOR:10531036 KEA:10531036 HPRD-phos:10531036 HPRD:10531036 ProtMapper:10531036
CYH2	Q99418	ARF6	P62330	Yes	Yes	No	WangKEGG-MEDICUSSIGNORHPRDHINTBioGRIDSPIKE_LC	HINT:17846866 HINT:9417041 HPRD:9417041 BioGRID:9417041 SIGNOR:14565977 SPIKE_LC:16189514
KPCG	P05129	CYH2	Q99418	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	SIGNOR:10531036 KEA:10531036 HPRD-phos:10531036 HPRD:10531036 ProtMapper:10531036

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CNKSR1 CYTH2	Q969H4 Q99418	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometryWestern blotting	1	34265469

Sequence, Structure & Domains

Sequences

Length

400

Mass

46,546

Sequence

MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99418-1; Sequence=Displayed; Name=2; IsoId=Q99418-2; Sequence=VSP_006036

Alternative Sequence

272; Missing (in isoform 2)

3D Structural Models

Turn

217..220

Helix

63..74; 76..85; 93..102; 108..115; 120..131; 140..149; 157..174; 182..200; 210..216; 228..240

Beta Strand

178..180; 221..224

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Coiled Coil

10..63

Domain (CC)

Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. The PH domain is necessary and sufficient for plasma membrane relocalization.; DOMAIN: Autoinhibited by its C-terminal basic region.; DOMAIN: The coiled coil domain is involved in interaction with CCDC120..

Domain (FT)

72..201; SEC7; 259..376; PH

Region

387..395; C-terminal autoinhibitory region

Clinical Relevance

Drugs

CLOTRIMAZOLE

Antibody

CAB014872 HPA060662

Interaction Protein

ENSG00000074706ENSG00000128271ENSG00000142675ENSG00000147144ENSG00000163362

Interaction Count

Interaction Dataset

intact_biogrid