Protein detail

CML1

Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)

Entry name CML1	UniProt ID Q99788	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)

Protein Class (3)

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

42..64; Helical; Name=1; 76..97; Helical; Name=2; 115..135; Helical; Name=3; 155..176; Helical; Name=4; 225..245; Helical; Name=5; 262..282; Helical; Name=6; 301..320; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000174600

Entrez Gene Symbol

CMKLR1

Gene Synonym

RVER1

Gene Description

Chemerin chemokine-like receptor 1

Chromosome

Position

108288044-108339317

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificretinaCell SpecificCone photoreceptor cells

Function & Pathway6

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (7)

Biological Process (3)

Reactome (3)

Mediation Categories (3)

Immune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence55

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	34265469 37403840

Sequence, Structure & Domains13

Sequences

Length

373

Mass

42,322

Sequence

MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q99788-1; Sequence=Displayed; Name=B; IsoId=Q99788-2; Sequence=VSP_001985

Alternative Sequence

1..2; Missing (in isoform B)

3D Structural Models

Turn

195..200; 283..285; 317..319

Helix

35..67; 73..100; 109..142; 144..150; 153..171; 173..176; 211..249; 257..282; 286..288; 291..316; 320..327

Beta Strand

101..103; 180..183; 186..189; 205..207; 254..256

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Compositional Bias

344..363; Polar residues; 364..373; Basic and acidic residues

Region

341..373; Disordered

Protein Families

Chemokine-like receptor (CMKLR) family

Sequence Similarities

Belongs to the chemokine-like receptor (CMKLR) family.

Clinical Relevance2

Drugs (3)

SAPROPTERIN NULL FENCLONINE

Antibody

HPA047865

Supporting Publications3

PMID	Title	Abstract
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available