Protein detail
CML1
Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
Protein symbol CML1 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
Protein Class
G-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
42..64; Helical; Name=1; 76..97; Helical; Name=2; 115..135; Helical; Name=3; 155..176; Helical; Name=4; 225..245; Helical; Name=5; 262..282; Helical; Name=6; 301..320; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
RVER1
Gene Description
Chemerin chemokine-like receptor 1
Chromosome
12
Position
108288044-108339317
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificretinaCell SpecificCone photoreceptor cells
Function & Pathway
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
373
Mass
42,322
Sequence
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q99788-1; Sequence=Displayed; Name=B; IsoId=Q99788-2; Sequence=VSP_001985
Alternative Sequence
1..2; Missing (in isoform B)
3D Structural Models
Turn
195..200; 283..285; 317..319
Helix
35..67; 73..100; 109..142; 144..150; 153..171; 173..176; 211..249; 257..282; 286..288; 291..316; 320..327
Beta Strand
101..103; 180..183; 186..189; 205..207; 254..256
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
344..363; Polar residues; 364..373; Basic and acidic residues
Region
341..373; Disordered
Protein Families
Chemokine-like receptor (CMKLR) family
Sequence Similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Clinical Relevance
Antibody