Protein detail
CIB1
Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)
Entry name CIB1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 17 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CIBKIPSIP2-28
Gene Description
Calcium and integrin binding 1
Chromosome
15
Position
90229975-90234047
Supporting publications (n)
17
EVMP confidence score
0.72
Fluorescence & Localization
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component (22)
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005813 centrosome
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
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Molecular Function (8)
- GO:0000287 magnesium ion binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008427 calcium-dependent protein kinase inhibitor activity
- GO:0030291 protein serine/threonine kinase inhibitor activity
- GO:0031267 small GTPase binding
- GO:0043495 protein-membrane adaptor activity
- GO:0044325 transmembrane transporter binding
Biological Process (3)
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence20
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CIB1 | PRKD2 | Q9BZL6 | S | 78 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| apical_cell_membrane | plasma_membrane | UniProt_location | |||||
| apical_cell_membrane | plasma_membrane | Ramilowski_location | |||||
| plasma_membrane | plasma_membrane | Ramilowski_location |
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Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CIB1 | Q99828 | COMPLEX:P05106_P08514 | Yes | Yes | SIGNOR | SIGNOR:16418530 | ||
| CHIP | Q9UNE7 | CIB1 | Q99828 | Yes | Yes | SIGNOR | SIGNOR:33082516 | |
| CIB1 | Q99828 | ITA2B | P08514 | Yes | Yes | MPPISIGNORHPRDHINTLMPIDLit-BM-17 | HINT:9030514LMPID:20034469LMPID:9030514HPRD:9030514Lit-BM-17:9030514HINT:10358085MPPI:10358085SIGNOR:11756406 | |
| RAC3 | P60763 | CIB1 | Q99828 | Yes | Yes | HPRDLit-BM-17SIGNOR | HPRD:11756406Lit-BM-17:11756406SIGNOR:11756406 | |
| KPCD2 | Q9BZL6 | CIB1 | Q99828 | Yes | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23503467 |
Protein Complex Composition (2)
Sequence, Structure & Domains
Sequences
Length
191
Mass
21,703
Sequence
MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99828-1; Sequence=Displayed; Name=2; Synonyms=CIB1a; IsoId=Q99828-2; Sequence=VSP_053740
Alternative Sequence
29; L -> LSVYVVLAPHLVDNEQQARSGNEHTGRPIAENTDSSPLSTR (in isoform 2)
3D Structural Models
Turn
18..20; 49..51
Helix
14..16; 24..35; 40..42; 45..48; 55..58; 62..65; 70..77; 88..98; 104..115; 125..136; 146..160; 170..178; 181..190
Beta Strand
81..86; 120..123; 137..139; 165..168
3D Structure
NMR spectroscopy (5); X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels.
Domain (FT)
103..138; EF-hand 1; 148..183; EF-hand 2
Clinical Relevance
Supporting Publications17
| PMID | Title | Related sentences |
|---|---|---|
| 30875722 | Human Heart Explant-Derived Extracellular Vesicles: Characterization and Effects on the In Vitro Recellularization of Decellularized Heart Valves. | No related sentences available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No related sentences available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No related sentences available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 34576246 | Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators. | No related sentences available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |
| 37204515 | Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No related sentences available |
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