Protein detail
PD1L2
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
Protein symbol PD1L2 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
Protein Class
Cancer-related genesCD markersPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Predicted secreted proteins
- CD markers
- Cancer-related genes
Transmembrane
221..241; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
B7-DCbA574F11.2BtdcCD273PD-L2PDL2
Gene Description
Programmed cell death 1 ligand 2
Chromosome
9
Position
5510531-5571282
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Predicted secreted proteins
- CD markers
- Cancer-related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-389948 co inhibition by pd 1
- R-hsa-9931295 pd l1 cd274 glycosylation and translocation to plasma membrane
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909615 regulation of pd l1 cd274 post translational modification
- R-hsa-388841 regulation of t cell activation by cd28 family
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
Page 6 of 6Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
273
Mass
30,957
Sequence
MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PD-L2I, Type I; IsoId=Q9BQ51-1; Sequence=Displayed; Name=2; Synonyms=PD-L2II, Type II; IsoId=Q9BQ51-2; Sequence=VSP_013740; Name=3; Synonyms=PD-L2III, Type III; IsoId=Q9BQ51-3; Sequence=VSP_013738, VSP_013739
Alternative Sequence
121..211; ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQS -> G (in isoform 2); 121..182; ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRL -> DGTQDPSNLAASHFHPLLHHCFHFHSHSDSPKKTTLSKAVFFKRHNKKTCHHNKEGSEQCYL (in isoform 3); 183..273; Missing (in isoform 3)
3D Structural Models
Helix
77..82; 94..96; 220..250
Beta Strand
22..24; 29..33; 38..45; 53..62; 84..91; 98..106; 109..120
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
21..118; Ig-like V-type; 122..203; Ig-like C2-type
Protein Families
- Immunoglobulin superfamily
- BTN/MOG family
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.