Protein detail

CYBC1

Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros)

Entry name
CYBC1
UniProt ID
Q9BQA9
EVMP confidence score
0.53
Supporting publications (n)
2
Transmembrane count
1
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros)
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Disease related genes
  • Predicted intracellular proteins
Transmembrane
20..42; Helical
Transmembrane Count
1
Ensembl
ENSG00000178927
Entrez Gene Symbol
CYBC1
Gene Synonym (4)
C17orf62ErosFLJ90469MGC4368
Gene Description
Cytochrome b-245 chaperone 1
Chromosome
17
Position
82440912-82450829
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
CYBC1 fluorescence
Cell SpecificChoroid plexus epithelial cells
Function & Pathway
Protein Function (3)
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (2)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembrane_predictedPhobius
transmembrane_tmhmmtransmembrane_predictedAlmen2009
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass spectrometryMass spectrometry [LTQ-FT Ultra]3223294222316151328396511
Sequence, Structure & Domains

Sequences

Length
187
Mass
20,774
Sequence
MYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYFGKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEAGDPASQS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQA9-1; Sequence=Displayed; Name=2; IsoId=Q9BQA9-2; Sequence=VSP_046335
Alternative Sequence
29..42; Missing (in isoform 2)

3D Structural Models

3D Structure
Electron microscopy (1)

Domain & Motif Annotations

Protein Families
CYBC1 family
Sequence Similarities
Belongs to the CYBC1 family.
Clinical Relevance
Disease Involvement (2)
Chronic granulomatous diseaseDisease variant
Related Diseases
Chronic granulomatous disease
Antibody
HPA045696
Supporting Publications2
PMIDTitleRelated sentences
27487081Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.No related sentences available
38014595Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.No related sentences available