Protein detail

FSP1

Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)

Entry name
FSP1
UniProt ID
Q9BRQ8
EVMP confidence score
0.38
Supporting publications (n)
3
Transmembrane count
1
Protein classification
Predicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Transmembrane
7..27; Helical
Transmembrane Count
1
Ensembl
ENSG00000042286
Entrez Gene Symbol
AIFM2
Gene Synonym (4)
AMIDFLJ14497FSP1PRG3
Gene Description
Apoptosis inducing factor mitochondria associated 2
Chromosome
10
Position
70098223-70132934
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
KEGG
hsa04115 p53 signaling pathway
Reactome (4)
Mediation Categories
Other mediation
Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYesNoNoNoNo
ecmecmOmniPathYesNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneLOCATENoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryR Sequencing6381133683732247533936570401894973614683438207106
Sequence, Structure & Domains8

Sequences

Length
373
Mass
40,527
Sequence
MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRQ8-1; Sequence=Displayed; Name=2; IsoId=Q9BRQ8-2; Sequence=VSP_052047, VSP_052048
Alternative Sequence
99..138; Missing (in isoform 2); 206; S -> SLLG (in isoform 2)

3D Structural Models

3D Structure
X-ray crystallography (6)

Domain & Motif Annotations

Protein Families
FAD-dependent oxidoreductase family
Sequence Similarities
Belongs to the FAD-dependent oxidoreductase family.
Clinical Relevance5
Drugs
VITAMIN K
Antibody (3)
HPA028961HPA042309HPA075576
Interaction Protein
ENSG00000138100
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications3
PMIDTitleAbstract
33919183Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry.No abstract available
36797805Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases.No abstract available
39766158A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.No abstract available