Protein detail
FSP1
Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
Entry name FSP1 | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count 1 | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Transmembrane
7..27; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
AMIDFLJ14497FSP1PRG3
Gene Description
Apoptosis inducing factor mitochondria associated 2
Chromosome
10
Position
70098223-70132934
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
373
Mass
40,527
Sequence
MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRQ8-1; Sequence=Displayed; Name=2; IsoId=Q9BRQ8-2; Sequence=VSP_052047, VSP_052048
Alternative Sequence
99..138; Missing (in isoform 2); 206; S -> SLLG (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Protein Families
FAD-dependent oxidoreductase family
Sequence Similarities
Belongs to the FAD-dependent oxidoreductase family.