Protein detail

TTYH2

Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)

Protein symbol TTYH2	UniProt ID Q9BSA4	EVMP score 0.25
Frequency 1	Transmembrane count 5	Protein classification

Basic Information

Protein Names

Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)

Protein Function

Transporters:Transporter channels and pores

Transmembrane

45..65; Helical; Name=1; 88..108; Helical; Name=2; 214..234; Helical; Name=3; 241..261; Helical; Name=4; 389..409; Helical; Name=5

Transmembrane Count

Ensembl

ENSG00000141540

Entrez Gene Symbol

TTYH2

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificgallbladderCell SpecificEnteric stem cellsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
chloride_channels	transporter	Surfaceome	No	Yes	No	Yes	No
tweety	transporter	Surfaceome	No	Yes	No	Yes	No
channels	transporter	Surfaceome	No	Yes	No	Yes	No
ion_channel	ion_channel	DGIdb	No	Yes	No	Yes	No
tweety_chloride	ion_channel	HGNC	No	Yes	No	Yes	No
ion_channel	ion_channel	HGNC	No	Yes	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NED4L	Q96PU5	TTYH2	Q9BSA4	Yes	No	Yes	WangSIGNOR	SIGNOR:18577513

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
APOE MANSC1 PLEKHB1 TOM1L1 TP53I11 TRAM2 TTYH2	O14683 O75674 P02649 Q15035 Q9BSA4 Q9H8J5 Q9UF11	0:0:0:0:0:0:0	hu.MAP2
APOE MANSC1 TRAM2 TTYH2	P02649 Q15035 Q9BSA4 Q9H8J5	0:0:0:0	hu.MAP2
TTYH2	Q9BSA4	2	PDB	PDB:9g6xPDB:7p5mPDB:9g71PDB:7p54

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	1	29148239

Sequence, Structure & Domains

Sequences

Length

534

Mass

58,772

Sequence

MQAARVDYIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNLIFLVAYLVCACHCRRDDAVQTKQHHSCCITWTAVVAGLICCAAVGVGFYGNSETNDGAYQLMYSLDDANHTFSGIDALVSGTTQKMKVDLEQHLARLSEIFAARGDYLQTLKFIQQMAGSVVVQLSGLPVWREVTMELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKCLLASMLCCGALSLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYCSQSGSSPFQQTLTTFQRALTTMQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQAWRMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPAQTISNAPVSEYMNQAMLFGRNPRYENVPLIGRASPPPTYSPSMRATYLSVADEHLRHYGNQFPA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSA4-1; Sequence=Displayed; Name=2; IsoId=Q9BSA4-2; Sequence=VSP_040567

Alternative Sequence

1..321; Missing (in isoform 2)

3D Structural Models

Turn

161..163

Helix

12..18; 39..71; 89..160; 165..186; 192..236; 239..275; 277..284; 291..298; 309..336; 342..364; 367..382; 385..408; 410..415

Beta Strand

25..27; 285..289; 302..304

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Motif

164..166; RGD; 506..509; PY-motif; mediates interaction with NEDD4L

Protein Families

Tweety family

Sequence Similarities

Belongs to the tweety family.

Clinical Relevance

Interaction Protein

ENSG00000129083

Interaction Count

Interaction Dataset

intact_biogrid