Protein detail
TTYH2
Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)
Entry name TTYH2 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count 5 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)
Protein Function
Transporters:Transporter channels and pores
Transmembrane
45..65; Helical; Name=1; 88..108; Helical; Name=2; 214..234; Helical; Name=3; 241..261; Helical; Name=4; 389..409; Helical; Name=5
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificgallbladderCell SpecificEnteric stem cellsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence33
Ligand-Receptor Signaling (28)
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | Almen2009 | Yes | Yes | |||
| tweety_chloride | ion_channel | Almen2009 | Yes | Yes | |||
| transporter | transporter | OmniPath | Yes | Yes | |||
| ion_channel | ion_channel | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NED4L | Q96PU5 | TTYH2 | Q9BSA4 | Yes | Yes | WangSIGNOR | SIGNOR:18577513 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| APOEMANSC1PLEKHB1TOM1L1TP53I11TRAM2TTYH2 | O14683O75674P02649Q15035Q9BSA4Q9H8J5Q9UF11 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| APOEMANSC1TRAM2TTYH2 | P02649Q15035Q9BSA4Q9H8J5 | 0:0:0:0 | hu.MAP2 | |||
| TTYH2 | Q9BSA4 | 2 | PDB | PDB:9g6xPDB:7p5mPDB:9g71PDB:7p54 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 29148239 |
Sequence, Structure & Domains
Sequences
Length
534
Mass
58,772
Sequence
MQAARVDYIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNLIFLVAYLVCACHCRRDDAVQTKQHHSCCITWTAVVAGLICCAAVGVGFYGNSETNDGAYQLMYSLDDANHTFSGIDALVSGTTQKMKVDLEQHLARLSEIFAARGDYLQTLKFIQQMAGSVVVQLSGLPVWREVTMELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKCLLASMLCCGALSLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYCSQSGSSPFQQTLTTFQRALTTMQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQAWRMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPAQTISNAPVSEYMNQAMLFGRNPRYENVPLIGRASPPPTYSPSMRATYLSVADEHLRHYGNQFPA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSA4-1; Sequence=Displayed; Name=2; IsoId=Q9BSA4-2; Sequence=VSP_040567
Alternative Sequence
1..321; Missing (in isoform 2)
3D Structural Models
Turn
161..163
Helix
12..18; 39..71; 89..160; 165..186; 192..236; 239..275; 277..284; 291..298; 309..336; 342..364; 367..382; 385..408; 410..415
Beta Strand
25..27; 285..289; 302..304
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Motif
164..166; RGD; 506..509; PY-motif; mediates interaction with NEDD4L
Protein Families
Tweety family
Sequence Similarities
Belongs to the tweety family.
Clinical Relevance
Interaction Protein
ENSG00000129083
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |