Protein detail

TTYH2

Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)

Protein symbol TTYH2	UniProt ID Q9BSA4	EVMP score 0.25
Frequency 1	Transmembrane count 5	Protein classification

Basic Information

Protein Names

Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2)

Protein Function

Transporters:Transporter channels and pores

Transmembrane

45..65; Helical; Name=1; 88..108; Helical; Name=2; 214..234; Helical; Name=3; 241..261; Helical; Name=4; 389..409; Helical; Name=5

Transmembrane Count

Ensembl

ENSG00000141540

Entrez Gene Symbol

TTYH2

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificgallbladderCell SpecificEnteric stem cellsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	Almen2009	No	Yes	No	Yes	No
tweety_chloride	ion_channel	Almen2009	No	Yes	No	Yes	No
transporter	transporter	OmniPath	No	Yes	No	Yes	No
ion_channel	ion_channel	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NED4L	Q96PU5	TTYH2	Q9BSA4	Yes	No	Yes	WangSIGNOR	SIGNOR:18577513

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
APOE MANSC1 PLEKHB1 TOM1L1 TP53I11 TRAM2 TTYH2	O14683 O75674 P02649 Q15035 Q9BSA4 Q9H8J5 Q9UF11	0:0:0:0:0:0:0	hu.MAP2
APOE MANSC1 TRAM2 TTYH2	P02649 Q15035 Q9BSA4 Q9H8J5	0:0:0:0	hu.MAP2
TTYH2	Q9BSA4	2	PDB	PDB:9g6xPDB:7p5mPDB:9g71PDB:7p54

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	1	29148239

Sequence, Structure & Domains

Sequences

Length

534

Mass

58,772

Sequence

MQAARVDYIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNLIFLVAYLVCACHCRRDDAVQTKQHHSCCITWTAVVAGLICCAAVGVGFYGNSETNDGAYQLMYSLDDANHTFSGIDALVSGTTQKMKVDLEQHLARLSEIFAARGDYLQTLKFIQQMAGSVVVQLSGLPVWREVTMELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKCLLASMLCCGALSLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYCSQSGSSPFQQTLTTFQRALTTMQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQAWRMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPAQTISNAPVSEYMNQAMLFGRNPRYENVPLIGRASPPPTYSPSMRATYLSVADEHLRHYGNQFPA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BSA4-1; Sequence=Displayed; Name=2; IsoId=Q9BSA4-2; Sequence=VSP_040567

Alternative Sequence

1..321; Missing (in isoform 2)

3D Structural Models

Turn

161..163

Helix

12..18; 39..71; 89..160; 165..186; 192..236; 239..275; 277..284; 291..298; 309..336; 342..364; 367..382; 385..408; 410..415

Beta Strand

25..27; 285..289; 302..304

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Motif

164..166; RGD; 506..509; PY-motif; mediates interaction with NEDD4L

Protein Families

Tweety family

Sequence Similarities

Belongs to the tweety family.

Clinical Relevance

Interaction Protein

ENSG00000129083

Interaction Count

Interaction Dataset

intact_biogrid