Protein detail
ZNF2
Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)
Entry name ZNF2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
A1-5Zfp661ZNF661
Gene Description
Zinc finger protein 2
Chromosome
2
Position
95165432-95184317
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specifichippocampal dentate gyrusBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells
Function & Pathway6
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence101
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (95)
95 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Size Exclusion Chromatography | Flow cytometryMORPH | 1 | 41216884 |
Sequence, Structure & Domains11
Sequences
Length
425
Mass
48,707
Sequence
MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVMLENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASDKKSEGSLRECLGRQSPLCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSRHLMSHTGESPYECSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECTVCGKVFSSKSSVIQHQRRYAKQGID
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9BSG1-2; Sequence=Displayed; Name=3; IsoId=Q9BSG1-3; Sequence=VSP_060238; Name=4; IsoId=Q9BSG1-4; Sequence=VSP_060237
Alternative Sequence
1..42; Missing (in isoform 3); 54..91; Missing (in isoform 4)
Domain & Motif Annotations
Compositional Bias
93..110; Basic and acidic residues; 144..154; Basic and acidic residues
Zinc Finger
173..195; C2H2-type 1; 201..223; C2H2-type 2; 229..251; C2H2-type 3; 257..279; C2H2-type 4; 285..307; C2H2-type 5; 313..335; C2H2-type 6; 341..363; C2H2-type 7; 369..391; C2H2-type 8; 397..419; C2H2-type 9; degenerate
Domain (FT)
14..85; KRAB
Region
86..110; Disordered; 122..163; Disordered
Protein Families
Krueppel C2H2-type zinc-finger protein family
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000130726
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38071653 | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. | No abstract available |