Protein detail

ZNF2

Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)

Protein symbol ZNF2	UniProt ID Q9BSG1	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661)

Protein Class

Predicted intracellular proteinsTranscription factors

Protein Function

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000275111

Entrez Gene Symbol

ZNF2

Gene Synonym

A1-5Zfp661ZNF661

Gene Description

Zinc finger protein 2

Chromosome

Position

95165432-95184317

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specifichippocampal dentate gyrusBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component

GO:0005634 nucleus

Molecular Function

Biological Process

Reactome

R-hsa-73857 rna polymerase ii transcription

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

95 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
SCAND1 ZNF24 ZSCAN30 ZSCAN32	P17028 P57086 Q86W11 Q9NX65	0:0:0:0	hu.MAP2
SCAND1 ZNF24 ZSCAN32	P17028 P57086 Q9NX65	0:0:0	hu.MAP2
ZKSCAN3 ZNF24 ZNF394 ZSCAN30 ZSCAN32	P17028 Q53GI3 Q86W11 Q9BRR0 Q9NX65	0:0:0:0:0	hu.MAP2
KBTBD7 LRIF1 ZNF24	P17028 Q5T3J3 Q8WVZ9	1:1:1	CompleatCFinder	Compleat:HC8685
FBXL5 MAPK6 MAPKAPK5 ZNF28 ZNF468 ZNF7	P17035 P17097 Q16659 Q5VIY5 Q8IW41 Q9UKA1	0:0:0:0:0:0	hu.MAP2
FBXL5 MAPK6 MAPKAPK5 ZNF28 ZNF468	P17035 Q16659 Q5VIY5 Q8IW41 Q9UKA1	0:0:0:0:0	hu.MAP2
CCND1 CCND2 CCND3 CDKN1A CDKN1B CDKN1C ZNF2	P24385 P30279 P30281 P38936 P46527 P49918 Q9BSG1	0:0:0:0:0:0:0	hu.MAP2
CCND3 ZNF2	P30281 Q9BSG1	0:0	hu.MAPhu.MAP2
CBX1 CBX3 CBX5 DYNLL1 HSPA14 POGZ ZNF283	P45973 P63167 P83916 Q0VDF9 Q13185 Q7Z3K3 Q8N7M2	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5460
ZNF280A ZNF280B	P59817 Q86YH2	0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Size Exclusion Chromatography	Flow cytometryMORPH	1	41216884

Sequence, Structure & Domains

Sequences

Length

425

Mass

48,707

Sequence

MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVMLENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASDKKSEGSLRECLGRQSPLCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSRHLMSHTGESPYECSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECTVCGKVFSSKSSVIQHQRRYAKQGID

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9BSG1-2; Sequence=Displayed; Name=3; IsoId=Q9BSG1-3; Sequence=VSP_060238; Name=4; IsoId=Q9BSG1-4; Sequence=VSP_060237

Alternative Sequence

1..42; Missing (in isoform 3); 54..91; Missing (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

93..110; Basic and acidic residues; 144..154; Basic and acidic residues

Zinc Finger

173..195; C2H2-type 1; 201..223; C2H2-type 2; 229..251; C2H2-type 3; 257..279; C2H2-type 4; 285..307; C2H2-type 5; 313..335; C2H2-type 6; 341..363; C2H2-type 7; 369..391; C2H2-type 8; 397..419; C2H2-type 9; degenerate

Domain (FT)

14..85; KRAB

Region

86..110; Disordered; 122..163; Disordered

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance

Antibody

HPA041358

Interaction Protein

ENSG00000130726

Interaction Count

Interaction Dataset

biogrid_bioplex